The reaction of trichloroethanal with water is a nucleophilic addition reaction. It can be catalysed by small amounts of hydroxide ions, OH-. Complete the diagram below to suggest a mechanism for this reaction. Show all the relevant dipoles and curly arrows. Cl CL C C CI TO O H H CL O CI CI-C-C-H H O H The recommended adult dose of chloral hydrate as a sedative is 250 mg, three times a day. Calculate the mass of trichloroethanal you would need to react with water to make one week's supply of chloral hydrate for an adult, assuming a 60% yield. M₁: chloral hydrate, 165.5; trichloroethanal, 147.5

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The reaction of trichloroethanal with water is a nucleophilic addition reaction. It can be
catalysed by small amounts of hydroxide ions, OH-.
Complete the diagram below to suggest a mechanism for this reaction. Show all the relevant
dipoles and curly arrows.
Cl
CI
C C
CI
TO
O
H
H
CI
O
CI
CI-C-C-H
H
O
H
The recommended adult dose of chloral hydrate as a sedative is 250 mg, three times a day.
Calculate the mass of trichloroethanal you would need to react with water to make one
week's supply of chloral hydrate for an adult, assuming a 60% yield.
M₁: chloral hydrate, 165.5; trichloroethanal, 147.5
Transcribed Image Text:The reaction of trichloroethanal with water is a nucleophilic addition reaction. It can be catalysed by small amounts of hydroxide ions, OH-. Complete the diagram below to suggest a mechanism for this reaction. Show all the relevant dipoles and curly arrows. Cl CI C C CI TO O H H CI O CI CI-C-C-H H O H The recommended adult dose of chloral hydrate as a sedative is 250 mg, three times a day. Calculate the mass of trichloroethanal you would need to react with water to make one week's supply of chloral hydrate for an adult, assuming a 60% yield. M₁: chloral hydrate, 165.5; trichloroethanal, 147.5
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