The rate at which a certain drug is eliminated by the body follows first-order kinetics, with a half life of 46 minutes. Suppose in a particular patient the concentration of this drug in the bloodstream immediately after injection is 1.1 ug/mL. What will the concentration be 92 minutes later? Round your answer to 2 significant digits.

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**Understanding Drug Elimination Kinetics: A Practical Example**

The rate at which a certain drug is eliminated by the body follows first-order kinetics, with a half-life of 46 minutes.

Suppose in a particular patient the concentration of this drug in the bloodstream immediately after injection is 1.1 µg/mL. What will the concentration be 92 minutes later?

**Solution:**

Given data:
- Initial concentration (C₀) = 1.1 µg/mL
- Half-life (t₁/₂) = 46 minutes
- Time elapsed (t) = 92 minutes

We apply the first-order kinetics elimination formula:
\[ C = C₀ \times \left(\frac{1}{2}\right)^{\frac{t}{t_{1/2}}} \]

Let's calculate the concentration (C) of the drug after 92 minutes:

\[ C = 1.1 \times \left(\frac{1}{2}\right)^{\frac{92}{46}} \]
\[ C = 1.1 \times \left(\frac{1}{2}\right)^{2} \]
\[ C = 1.1 \times \frac{1}{4} \]
\[ C = 1.1 \times 0.25 \]
\[ C = 0.275 \]

Rounding the answer to 2 significant digits:
\[ C \approx 0.28 \: \text{µg/mL} \]

Thus, the concentration of the drug in the bloodstream 92 minutes after injection will be approximately 0.28 µg/mL.
Transcribed Image Text:**Understanding Drug Elimination Kinetics: A Practical Example** The rate at which a certain drug is eliminated by the body follows first-order kinetics, with a half-life of 46 minutes. Suppose in a particular patient the concentration of this drug in the bloodstream immediately after injection is 1.1 µg/mL. What will the concentration be 92 minutes later? **Solution:** Given data: - Initial concentration (C₀) = 1.1 µg/mL - Half-life (t₁/₂) = 46 minutes - Time elapsed (t) = 92 minutes We apply the first-order kinetics elimination formula: \[ C = C₀ \times \left(\frac{1}{2}\right)^{\frac{t}{t_{1/2}}} \] Let's calculate the concentration (C) of the drug after 92 minutes: \[ C = 1.1 \times \left(\frac{1}{2}\right)^{\frac{92}{46}} \] \[ C = 1.1 \times \left(\frac{1}{2}\right)^{2} \] \[ C = 1.1 \times \frac{1}{4} \] \[ C = 1.1 \times 0.25 \] \[ C = 0.275 \] Rounding the answer to 2 significant digits: \[ C \approx 0.28 \: \text{µg/mL} \] Thus, the concentration of the drug in the bloodstream 92 minutes after injection will be approximately 0.28 µg/mL.
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