The rate at which a certain drug is eliminated by the body follows first-order kinetics, with a half life of 33 minutes. Suppose in a particular patient the concentration of this drug in the bloodstream immediately after injection is 0.98 µg/mL. What will the concentration be 165 minutes later? Round your answer to 2 significant digits. mL 3 ? x10 X

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**Drug Elimination Kinetics Educational Exercise**

Title: First-Order Kinetics in Drug Elimination

---

**Topic:** Understanding First-Order Kinetics in Drug Elimination from the Body

**Objective:** Learn how to calculate the concentration of a drug in the bloodstream over time using first-order kinetics and the concept of half-life.

### Problem Statement:

The rate at which a certain drug is eliminated by the body follows first-order kinetics, with a half-life of 33 minutes.

**Scenario:**
Suppose in a particular patient the concentration of this drug in the bloodstream immediately after injection is 0.98 μg/mL. What will the concentration be 165 minutes later?

**Instructions:**
- Round your answer to 2 significant digits.

**Data Given:**
- Initial concentration (C₀): 0.98 μg/mL
- Half-life (t₁/₂): 33 minutes
- Time elapsed (t): 165 minutes

**Objective:**
Calculate the concentration (C) of the drug in the bloodstream after 165 minutes.

### Solution Steps:

**Using the first-order kinetics formula:**

\[ C = C₀ \times \left( \frac{1}{2} \right)^{\frac{t}{t₁/₂}} \]

Where:
- \( C \) is the concentration after time \( t \).
- \( C₀ \) is the initial concentration.
- \( t \) is the time elapsed.
- \( t₁/₂ \) is the half-life.

Plug in the values:

\[ C = 0.98 \, \text{μg/mL} \times \left( \frac{1}{2} \right)^{\frac{165}{33}} \]

\[ \frac{165}{33} = 5 \]

\[ C = 0.98 \, \text{μg/mL} \times \left( \frac{1}{2} \right)^5 \]

\[ \left( \frac{1}{2} \right)^5 = \frac{1}{32} \]

\[ C = 0.98 \, \text{μg/mL} \times \frac{1}{32} \]

\[ C = 0.030625 \, \text{μg/mL} \]

**Rounded to 2 significant digits:**

\[
Transcribed Image Text:**Drug Elimination Kinetics Educational Exercise** Title: First-Order Kinetics in Drug Elimination --- **Topic:** Understanding First-Order Kinetics in Drug Elimination from the Body **Objective:** Learn how to calculate the concentration of a drug in the bloodstream over time using first-order kinetics and the concept of half-life. ### Problem Statement: The rate at which a certain drug is eliminated by the body follows first-order kinetics, with a half-life of 33 minutes. **Scenario:** Suppose in a particular patient the concentration of this drug in the bloodstream immediately after injection is 0.98 μg/mL. What will the concentration be 165 minutes later? **Instructions:** - Round your answer to 2 significant digits. **Data Given:** - Initial concentration (C₀): 0.98 μg/mL - Half-life (t₁/₂): 33 minutes - Time elapsed (t): 165 minutes **Objective:** Calculate the concentration (C) of the drug in the bloodstream after 165 minutes. ### Solution Steps: **Using the first-order kinetics formula:** \[ C = C₀ \times \left( \frac{1}{2} \right)^{\frac{t}{t₁/₂}} \] Where: - \( C \) is the concentration after time \( t \). - \( C₀ \) is the initial concentration. - \( t \) is the time elapsed. - \( t₁/₂ \) is the half-life. Plug in the values: \[ C = 0.98 \, \text{μg/mL} \times \left( \frac{1}{2} \right)^{\frac{165}{33}} \] \[ \frac{165}{33} = 5 \] \[ C = 0.98 \, \text{μg/mL} \times \left( \frac{1}{2} \right)^5 \] \[ \left( \frac{1}{2} \right)^5 = \frac{1}{32} \] \[ C = 0.98 \, \text{μg/mL} \times \frac{1}{32} \] \[ C = 0.030625 \, \text{μg/mL} \] **Rounded to 2 significant digits:** \[
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