the peptide sequence in single letter code is T N C H P, please hand draw a peptide diagram satisfied the following conditions * Show the position of all ‘heavy’ atoms with the appropriate letter (C, N, O, S etc.) and indicate the number of attached hydrogen atoms (no skeletal structures allowed). * Show all double bonds and/or partial double bonds. * Draw all ionisable groups as their most highly populated state at pH 7. * Make the peptide bond between the fourth residue and proline the cis isomer. * Show all other peptide bonds as trans. * Show the alpha carbon of every residue as tetrahedral and the L isomer. * All trigonal planar groups must be shown explicitly with appropriate geometry. 2. Give the name and three letter code for each amino acid in the peptide. 3. At pH 7, approximately what charge would be on your peptide? Explain your answer. 4. Can your peptide form intra/interchain disulfide bonds? Explain why/why not. 5. Will your peptide absorb UV (either strongly, weakly or negligibly) and is it fluorescent (either strongly, weakly or negligibly) ? Explain why/why not. 6. What is the probability that your peptide contains a cis peptide bond? Explain your answer.
the peptide sequence in single letter code is T N C H P, please hand draw a peptide diagram satisfied the following conditions * Show the position of all ‘heavy’ atoms with the appropriate letter (C, N, O, S etc.) and indicate the number of attached hydrogen atoms (no skeletal structures allowed). * Show all double bonds and/or partial double bonds. * Draw all ionisable groups as their most highly populated state at pH 7. * Make the peptide bond between the fourth residue and proline the cis isomer. * Show all other peptide bonds as trans. * Show the alpha carbon of every residue as tetrahedral and the L isomer. * All trigonal planar groups must be shown explicitly with appropriate geometry. 2. Give the name and three letter code for each amino acid in the peptide. 3. At pH 7, approximately what charge would be on your peptide? Explain your answer. 4. Can your peptide form intra/interchain disulfide bonds? Explain why/why not. 5. Will your peptide absorb UV (either strongly, weakly or negligibly) and is it fluorescent (either strongly, weakly or negligibly) ? Explain why/why not. 6. What is the probability that your peptide contains a cis peptide bond? Explain your answer.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
the peptide sequence in single letter code is T N C H P, please hand draw a peptide diagram satisfied the following conditions
* Show the position of all ‘heavy’ atoms with the appropriate letter (C, N, O, S etc.) and indicate the number of attached hydrogen atoms (no skeletal structures allowed).
* Show all double bonds and/or partial double bonds.
* Draw all ionisable groups as their most highly populated state at pH 7.
* Make the peptide bond between the fourth residue and proline the cis isomer.
* Show all other peptide bonds as trans.
* Show the alpha carbon of every residue as tetrahedral and the L isomer.
* All trigonal planar groups must be shown explicitly with appropriate geometry.
2. Give the name and three letter code for each amino acid in the peptide.
3. At pH 7, approximately what charge would be on your peptide? Explain your answer.
4. Can your peptide form intra/interchain disulfide bonds? Explain why/why not.
5. Will your peptide absorb UV (either strongly, weakly or negligibly) and is it fluorescent (either strongly, weakly or negligibly) ? Explain why/why not.
6. What is the probability that your peptide contains a cis peptide bond? Explain your answer.
Transcribed Image Text:12:40
< *14*
20233 17 F 12:39
the peptide sequence in single letter code is T N
CHP, please hand draw a peptide diagram
satisfied the following conditions
68
* Show the position of all 'heavy' atoms with the
appropriate letter (C, N, O, S etc.) and indicate
the number of attached hydrogen atoms (no
skeletal structures allowed).
* Show all double bonds and/or partial double
bonds.
* Draw all ionisable groups as their most highly
populated state at pH 7.
* Make the peptide bond between the fourth
residue and proline the cis isomer.
* Show all other peptide bonds as trans.
* Show the alpha carbon of every residue as
tetrahedral and the L isomer.
* All trigonal planar groups must be shown
explicitly with appropriate geometry.
2. Give the name and three letter code for each
amino acid in the peptide.
3. At pH 7, approximately what charge would be
on your peptide? Explain your answer.
4. Can your peptide form intra/interchain
disulfide bonds? Explain why/why not.
5. Will your peptide absorb UV (either strongly,
O-ongly, weak
Transcribed Image Text:12:40
< *14*
20233 17 F 12:39
the peptide sequence in single letter code is T N
CHP, please hand draw a peptide diagram
satisfied the following conditions
68
* Show the position of all 'heavy' atoms with the
appropriate letter (C, N, O, S etc.) and indicate
the number of attached hydrogen atoms (no
skeletal structures allowed).
* Show all double bonds and/or partial double
bonds.
* Draw all ionisable groups as their most highly
populated state at pH 7.
* Make the peptide bond between the fourth
residue and proline the cis isomer.
* Show all other peptide bonds as trans.
* Show the alpha carbon of every residue as
tetrahedral and the L isomer.
* All trigonal planar groups must be shown
explicitly with appropriate geometry.
2. Give the name and three letter code for each
amino acid in the peptide.
3. At pH 7, approximately what charge would be
on your peptide? Explain your answer.
4. Can your peptide form intra/interchain
disulfide bonds? Explain why/why not.
5. Will your peptide absorb UV (either strongly,
O-ongly, weak
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