The Organic Chemistry of Life Propose reasonable mechanisms for the following biochemical transformations. All necessary cofactors are shown. 2 Biological conversion of an aldehyde into a thioester. R'-SH NAD* tetrahedral intermediate H. SR

The Organic Chemistry of Life Propose reasonable mechanisms for the following biochemical transformations. All necessary cofactors are shown. 2 Biological conversion of an aldehyde into a thioester. R'-SH NAD* tetrahedral intermediate H. SR

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter19: Aldehydes And Ketones: Nucleophilic Addition Reactions

Section19.SE: Something Extra

Problem 28VC

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Concept explainers

Designing a Synthesis

Organic synthesis is a branch of chemical synthesis that involves the planned construction of organic compounds/molecules from smaller units that possess functional groups. Friedrich Wöhler was the first scientist who designed the synthesis of an organic compound, urea from inorganic starting materials silver cyanate with ammonium chloride via a simple, one-step synthesis.

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I’m struggling on making a reasonable mechanism for this transformation problem. Can you please elaborate the steps?

The Organic Chemistry of Life
Propose reasonable mechanisms for the following biochemical transformations. All necessary cofactors are
shown.
2 Biological conversion of an aldehyde into a thioester.
R-SH
NAD
tetrahedral
intermediate
H.
SR'

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