The mouse facility sends you the wrong knockout mice. For fun, you check levels of cholesterol and cholesterol precursors in the mice and find that the mice you mistakenly received have very low levels of cholesterol (similar to the case of dhcr7 (-/-) mice). These mice however have elevated levels of squalene in their serum and tissues. The enzymes in the pathway have been numbered for your convenience in the schematic below. Which enzyme number (enzyme 1-5) do you think is mutated in the knockout mouse you received? In one brief sentence, explain why you chose that enzyme. Geranyl-PP Enzyme 1 - Farnesyl-PP Enzyme 2 Squalene Enzyme 3 Lanosterol Enzyme 4 7-Dehydrocholesterol Enzyme 5 Cholesterol

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Spheres of physical activity

The spheres of physical activity experience include aspects of everyday life where physical activity is important. In general, the spheres recognize various purposes of physical activity in different contexts. The spheres of physical activity provide a broad basis for assessing the significance and prevalence of physical activity. There are seven spheres of physical activity experience.