Homework Help is Here – Start Your Trial Now!
Science
Biology
The human kidney helps control water and electrolyte balance and excretion of nitrogenous wastes. As water and solutes move through the nephron of the kidney, water is absorbed and transporters help transfer solutes in and out of the nephron. The urine is collected at the end of the nephron in a collecting duct and then transferred to the bladder. The sodium-glucose cotransporter-2 (SGLT2) is a Na+-glucose symport protein highly expressed in kidney epithelial cells lining the nephron. SGLT2 uses the Na+ gradient to transport glucose from the kidney nephron tubule into the epithelial cell cytosol. The glucose then returns to the bloodstream through passive transport out of the epithelial cells by the glucose transporter GLUT2. Blood glucose levels are higher than normal in people with type 2 diabetes. One goal of type 2 diabetes treatment is to lower blood glucose levels. One way to do so is to keep glucose in the nephron tubule where it can be transferred to the bladder and excreted. Sort each of the following potential treatments into those that would alter kidney function to lower blood glucose levels by increasing glucose excretion and those that would increase blood glucose levels by decreasing glucose excretion. Items (5 items) (Drag and drop into the appropriate area below) Activate the Na+-K+ pump to maintain the Na* gradient Categories Activate GLUT2 function Activate SGLT2 Na+-glucose symport function Inhibit the Na+- K+ pump to Inhibit SGLT2 Na+-glucose dissipate the Na+ gradient symport function Increase excretion Decrease excretion

The human kidney helps control water and electrolyte balance and excretion of nitrogenous wastes. As water and solutes move through the nephron of the kidney, water is absorbed and transporters help transfer solutes in and out of the nephron. The urine is collected at the end of the nephron in a collecting duct and then transferred to the bladder. The sodium-glucose cotransporter-2 (SGLT2) is a Na+-glucose symport protein highly expressed in kidney epithelial cells lining the nephron. SGLT2 uses the Na+ gradient to transport glucose from the kidney nephron tubule into the epithelial cell cytosol. The glucose then returns to the bloodstream through passive transport out of the epithelial cells by the glucose transporter GLUT2. Blood glucose levels are higher than normal in people with type 2 diabetes. One goal of type 2 diabetes treatment is to lower blood glucose levels. One way to do so is to keep glucose in the nephron tubule where it can be transferred to the bladder and excreted. Sort each of the following potential treatments into those that would alter kidney function to lower blood glucose levels by increasing glucose excretion and those that would increase blood glucose levels by decreasing glucose excretion. Items (5 items) (Drag and drop into the appropriate area below) Activate the Na+-K+ pump to maintain the Na* gradient Categories Activate GLUT2 function Activate SGLT2 Na+-glucose symport function Inhibit the Na+- K+ pump to Inhibit SGLT2 Na+-glucose dissipate the Na+ gradient symport function Increase excretion Decrease excretion

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question
The human kidney helps control water and electrolyte balance and excretion of nitrogenous wastes. As water and solutes move through the nephron of the kidney, water is absorbed and transporters help transfer solutes in and out of the nephron. The urine is collected at the end of the nephron in a collecting duct and then transferred to the bladder. The sodium-glucose cotransporter-2 (SGLT2) is a Na+-glucose symport protein highly expressed in kidney epithelial cells lining the nephron. SGLT2 uses the Na+ gradient to transport glucose from the kidney nephron tubule into the epithelial cell cytosol. The glucose then returns to the bloodstream through passive transport out of the epithelial cells by the glucose transporter GLUT2. Blood glucose levels are higher than normal in people with type 2 diabetes. One goal of type 2 diabetes treatment is to lower blood glucose levels. One way to do so is to keep glucose in the nephron tubule where it can be transferred to the bladder and excreted. Sort each of the following potential treatments into those that would alter kidney function to lower blood glucose levels by increasing glucose excretion and those that would increase blood glucose levels by decreasing glucose excretion. Items (5 items) (Drag and drop into the appropriate area below) Activate the Na+-K+ pump to maintain the Na* gradient Categories Activate GLUT2 function Activate SGLT2 Na+-glucose symport function Inhibit the Na+- K+ pump to Inhibit SGLT2 Na+-glucose dissipate the Na+ gradient symport function Increase excretion Decrease excretion
Transcribed Image Text:The human kidney helps control water and electrolyte balance and excretion of nitrogenous wastes. As water and solutes move through the nephron of the kidney, water is absorbed and transporters help transfer solutes in and out of the nephron. The urine is collected at the end of the nephron in a collecting duct and then transferred to the bladder. The sodium-glucose cotransporter-2 (SGLT2) is a Na+-glucose symport protein highly expressed in kidney epithelial cells lining the nephron. SGLT2 uses the Na+ gradient to transport glucose from the kidney nephron tubule into the epithelial cell cytosol. The glucose then returns to the bloodstream through passive transport out of the epithelial cells by the glucose transporter GLUT2. Blood glucose levels are higher than normal in people with type 2 diabetes. One goal of type 2 diabetes treatment is to lower blood glucose levels. One way to do so is to keep glucose in the nephron tubule where it can be transferred to the bladder and excreted. Sort each of the following potential treatments into those that would alter kidney function to lower blood glucose levels by increasing glucose excretion and those that would increase blood glucose levels by decreasing glucose excretion. Items (5 items) (Drag and drop into the appropriate area below) Activate the Na+-K+ pump to maintain the Na* gradient Categories Activate GLUT2 function Activate SGLT2 Na+-glucose symport function Inhibit the Na+- K+ pump to Inhibit SGLT2 Na+-glucose dissipate the Na+ gradient symport function Increase excretion Decrease excretion
Expert Solution
steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS