The human kidney helps control water and electrolyte balance and excretion of nitrogenous wastes. As water and solutes move through the nephron of the kidney, water is absorbed and transporters help transfer solutes in and out of the nephron. The urine is collected at the end of the nephron in a collecting duct and then transferred to the bladder. The sodium-glucose cotransporter-2 (SGLT2) is a Na+-glucose symport protein highly expressed in kidney epithelial cells lining the nephron. SGLT2 uses the Na+ gradient to transport glucose from the kidney nephron tubule into the epithelial cell cytosol. The glucose then returns to the bloodstream through passive transport out of the epithelial cells by the glucose transporter GLUT2. Blood glucose levels are higher than normal in people with type 2 diabetes. One goal of type 2 diabetes treatment is to lower blood glucose levels. One way to do so is to keep glucose in the nephron tubule where it can be transferred to the bladder and excreted. Sort each of the following potential treatments into those that would alter kidney function to lower blood glucose levels by increasing glucose excretion and those that would increase blood glucose levels by decreasing glucose excretion. Items (5 items) (Drag and drop into the appropriate area below) Activate the Na+-K+ pump to maintain the Na* gradient Categories Activate GLUT2 function Activate SGLT2 Na+-glucose symport function Inhibit the Na+- K+ pump to Inhibit SGLT2 Na+-glucose dissipate the Na+ gradient symport function Increase excretion Decrease excretion