43. The Hoffman rule states that:the alkene with less alkyl substituents is the major product in base-induced elimination reactionsthe more highly substituted carbocation is formed as the intermediate rather than the less highly substituted onethe alkene with more alkyl substituents is the major product in base-induced elimination reactionsthe less highly substituted carbocation is formed as the intermediate rather than the more highly substituted one

The Hofmann elimination process and the Hofmann rule is named after, the German chemist August…

Answered: The Hoffman rule states that: the…

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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43. The Hoffman rule states that:

the alkene with less alkyl substituents is the major product in base-induced elimination reactions
the more highly substituted carbocation is formed as the intermediate rather than the less highly substituted one
the alkene with more alkyl substituents is the major product in base-induced elimination reactions
the less highly substituted carbocation is formed as the intermediate rather than the more highly substituted one

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