The high presence of particular HLA immune system genes outside of Africa is a result of
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Recent research has suggested that modern humans interbred with Neanderthals and Denisovans, two extinct human species, outside of Africa. These interbreeding events resulted in the introduction of new genetic variants into the modern human gene pool, including variants of the HLA immune system genes. It is believed that some of these new genetic variants provided major adaptive benefits to the modern human populations that inherited them, which may have contributed to the success of modern humans as they spread across the globe.
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