The following image shows a Robertsonian translocation between chromosomes 13 and 21. This has the potential to cause Down Syndrome in offspring. The couple had 6 pregnancies. What is the probable cause for the two miscarriages you see in the pedigree? See the legend for more information. Briefly explain your answer. male female miscarriage chromosome 13 chromosome 21 Robertsonian translocation Carrier Normal der(13;21)(q10;q10)

The following image shows a Robertsonian translocation between chromosomes 13 and 21. This has the potential to cause Down Syndrome in offspring. The couple had 6 pregnancies. What is the probable cause for the two miscarriages you see in the pedigree? See the legend for more information. Briefly explain your answer. male female miscarriage chromosome 13 chromosome 21 Robertsonian translocation Carrier Normal der(13;21)(q10;q10)

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations

Section: Chapter Questions

Problem 3QP: A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13....

See similar textbooks

Similar questions

A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13. In discussing this discovery with a friend who is not a cytogeneticist, explain how you would describe this location, defining each term in the chromosome address 21q13.
Assume that a meiotic-nondisjunction event causes trisomy 8 in a newborn. If two of the three copies of chromosome 8 are absolutely identical, at what point during meiosis did the nondisjunction event take place?
In Neurospora, his2 mutants require the amino acidhistidine for growth, and lys4 mutants require theamino acid lysine. The two genes are on the samearm of the same chromosome, in the ordercentromere - his2 - lys4.A his2 mutant is mated with a lys4 mutant. Draw all ofthe possible ordered asci that could result from meioses in which the following events occurred, accountingfor the nutritional requirements for each ascospore.Ascospores without any copy of a chromosome willabort and die, turning white in the process.a. A single crossover between the centromere and his2b. A single crossover between his2 and lys4c. Nondisjunction during the first meiotic divisiond. Nondisjunction during the second meiotic divisione. A single crossover between the centromere andhis2, followed by nondisjunction during the firstmeiotic divisionf. A single crossover between his2 and lys4,followed by nondisjunction during the firstmeiotic division
A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?
A normal female is discovered with 45 chromosomes, one ofwhich exhibits a Robertsonian translocation containing most ofchromosomes 18 and 21. Discuss the possible outcomes in heroffspring when her husband contains a normal karyotype.
A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown? (b) Using a drawing, demonstrate how these chromosomeswould pair during meiosis. Be sure to label the differentsegments of the chromosomes.(c) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement? The woman in above problem has had two miscarriages. Shehas come to you, an established genetic counselor, with thesequestions:(a) If not, what is the chance that she could have a normalchild? Provide an informed response to her concerns
A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown? (b) Using a drawing, demonstrate how these chromosomeswould pair during meiosis. Be sure to label the differentsegments of the chromosomes.(c) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement? The woman in above problem has had two miscarriages. Shehas come to you, an established genetic counselor, with thesequestions:(a) Is there a genetic explanation of her frequent miscarriages?
A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. Q. What types of zygotes will develop when each of gametes produced by the man fuses with a normal gamete produced by the woman?
Imagine a germ cell for an animal that is 2n=4. Gene A and B are found on chromosome one, and the cell is homozygous for A(AA) and heterozygous for Bb. Gene D is found on chromosome 2 and the germ cell is heterozygous for the Allee of the gene (Dd). Meiosis for this germ cell results in the following four gametes, and one crossing over event during meiosis ABD, ABd, AbD, Abd. Draw the chromosomes in cell during metaphase of meiosis 1. Make sure to include chromosomes, the allele in the correct locations on the chromosomes AFTER the crossing over event, and spindle fibers.
The organism you are working with has the following chromosomes. Place the chromosomes of this organism onto the cell below such that the diagram accurately shows a primary meiocyte from this organism in metaphase I of meiosis. Note 1: Only place chromosomes you need. You don't need them all. Note 2: You can place the 'Blank Box' image if you don't think you need a chromosome at a particular position. Dashed linethe metaphase plate
Shown below are photomicrographs of Rhoeo tradescantia cells undergoing meiosis. Answer the following question for each of the photomicrographs: Identify the cytogenetic abnormality observed (ex. ring, chain, laggard, bridge). Identify the meiotic stage in which these aberrations are observed (as shown in the photomicrograph). Explain how these aberrations are formed and relate to the possible causal mutation(s). Will this result to sterile and/or fertile gametes? Explain.
A man who is a carrier of a translocated 15/21 chromosome marries a genotypically normal woman. a. Show the possible gametes that will be formed by this man if the translocated 15/21 chromosome synapses with chromosome 21 at Prophase I.