The following data were collected in a clinical trial to compare a new drug to a placebo for its effectiveness in lowering total serum cholesterol. New Drug (n=75) Placebo (n=75) Total Sample (n=150) Mean (SD) Total Serum Cholesterol 182.0 (24.5) 206.3 (21.8) 194.15 (23.2) % Patients with Total Cholesterol < 200 78.0% 65.0% 71.5% Generate the 95% confidence interval for the difference in mean total cholesterol levels between treatments
The following data were collected in a clinical trial to compare a new drug to a placebo for its effectiveness in lowering total serum cholesterol.
|
|
New Drug (n=75) |
Placebo (n=75) |
Total Sample (n=150) |
|
|
182.0 (24.5) |
206.3 (21.8) |
194.15 (23.2) |
|
% Patients with Total Cholesterol < 200 |
78.0% |
65.0% |
71.5% |
Generate the 95% confidence interval for the difference in mean total cholesterol levels between treatments
Generate a 95% confidence interval for the difference in proportions of all patients with total cholesterol < 200.
How many patients would be required to detect the difference in proportions observed in the current study with 80% power. A new investigation will be enrolling subjects to demonstrate the efficacy of the drug in individuals with high cholesterol at an early age. A two-sided test is planned at α = 0.05
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