The equilibrium idea means that if the reaction is reversible there will be four species in solution at one time, the acid, the base, the conjugate acid, and the conjugate base. Sometimes this is what is required, but at other times we need to choose bases that will completely deprotonate every molecule of acid, i.e. send the reaction completely to the right. These bases will include CH3CH2CH2CH,Li, NaNH2, and LIN(i-Pr)2. Weaker bases will include NAOH, NaOCH3, KOtBu, and NaOCH2CH3. For each of these bases, give the products formed when they react with H20, then use pKa values to get an idea of the relative base strengths of these compounds. You will provided 7 separate reactions.

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### Understanding Reaction Equilibria and Base Strengths

**Equilibrium Concept in Chemical Reactions**

In reversible chemical reactions, equilibrium is maintained by the presence of four species in the solution at any given time: the acid, the conjugate base, the conjugate acid, and the base. Sometimes, it is necessary to completely deprotonate every molecule of the acid, driving the reaction entirely to the right. This complete deprotonation requires strong bases.

**Examples of Strong Bases:**
- CH₃CH₂CH₂CH₂Li
- NaNH₂
- LiN(i-Pr)₂

**Examples of Weaker Bases:**
- NaOH
- NaOCH₃
- KOtBu
- NaOCH₂CH₃

**Analysis of Base Strengths**

For each of these bases, consider the reaction products when they interact with water (H₂O). Use **pKₐ** values to comprehend the relative strengths of these bases. This understanding is critical for recognizing how effectively these bases can drive reactions to completion.

You will be provided with seven separate reactions to analyze. Understanding these interactions helps in making informed decisions in chemical synthesis and analysis.
Transcribed Image Text:### Understanding Reaction Equilibria and Base Strengths **Equilibrium Concept in Chemical Reactions** In reversible chemical reactions, equilibrium is maintained by the presence of four species in the solution at any given time: the acid, the conjugate base, the conjugate acid, and the base. Sometimes, it is necessary to completely deprotonate every molecule of the acid, driving the reaction entirely to the right. This complete deprotonation requires strong bases. **Examples of Strong Bases:** - CH₃CH₂CH₂CH₂Li - NaNH₂ - LiN(i-Pr)₂ **Examples of Weaker Bases:** - NaOH - NaOCH₃ - KOtBu - NaOCH₂CH₃ **Analysis of Base Strengths** For each of these bases, consider the reaction products when they interact with water (H₂O). Use **pKₐ** values to comprehend the relative strengths of these bases. This understanding is critical for recognizing how effectively these bases can drive reactions to completion. You will be provided with seven separate reactions to analyze. Understanding these interactions helps in making informed decisions in chemical synthesis and analysis.
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