The binding of oxygen by hemoglobin (Hb), giving oxyhemoglobin (HbO2), is partially regulated by the concentration of H3O+ and dissolved CO2 in the blood. Although the equilibrium is complicated, it can be summarized as HbO2(aq)+H3O+(aq)+CO2(g)⇌CO2−Hb−H++O2(g)+H2O(l) 1+3=4 (a) Write the equilibrium constant expression for this reaction. (b) Explain why the production of lactic acid and CO2 in a muscle during exertion stimulates release of O2 from the oxyhemoglobin in the blood passing through the muscle.

Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter16: Solubility And Precipitation Equilibria
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The binding of oxygen by hemoglobin (Hb), giving oxyhemoglobin (HbO2), is partially regulated
by the concentration of H3O+ and dissolved CO2 in the blood. Although the equilibrium is
complicated, it can be summarized as
HbO2(aq)+H3O+(aq)+CO2(g)⇌CO2−Hb−H++O2(g)+H2O(l) 1+3=4
(a) Write the equilibrium constant expression for this reaction.
(b) Explain why the production of lactic acid and CO2 in a muscle during exertion stimulates
release of O2 from the oxyhemoglobin in the blood passing through the muscle.

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