The antiviral Tamiflu demonstrates mixed inhibition kinetics. Remember mixed inhibition can be characterized by the equation: v= Vm -S For the following data: 0μM Inh 70μM Inh 210μM Inh SμM v FLU/min v FLU/min v FLU/min 250 90.9 47.6 23.8 150 83.3 37.0 17.9 100 76.9 30.3 13.5 50 50.0 19.6 7.7 25 34.5 10.2 4.2 a. What is the value of Km and Vm? b. What is the value of Ki and Kia? Km +S 1+
The antiviral Tamiflu demonstrates mixed inhibition kinetics. Remember mixed inhibition can be characterized by the equation: v= Vm -S For the following data: 0μM Inh 70μM Inh 210μM Inh SμM v FLU/min v FLU/min v FLU/min 250 90.9 47.6 23.8 150 83.3 37.0 17.9 100 76.9 30.3 13.5 50 50.0 19.6 7.7 25 34.5 10.2 4.2 a. What is the value of Km and Vm? b. What is the value of Ki and Kia? Km +S 1+
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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
Transcribed Image Text:The antiviral Tamiflu demonstrates mixed inhibition kinetics. Remember mixed
inhibition can be characterized by the equation: v=
Vm
-S
For the following data:
0μM Inh
70μM Inh
210μM Inh
SμM
v FLU/min
v FLU/min
v FLU/min
250
90.9
47.6
23.8
150
83.3
37.0
17.9
100
76.9
30.3
13.5
50
50.0
19.6
7.7
25
34.5
10.2
4.2
a. What is the value of Km and Vm?
b. What is the value of Ki and Kia?
Km
+S
1+
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