The aim of this experimen solution on the distribution coefficient of a drug, in this case benzoic acid. In order to LdEy out this investigation, a pre-prepared 0.001998 mol dm stock solution of benzoic acid in ethyl acetate was used to prepare standard solutions of varying concentrations whose absorbances were measured to produce a calibration plot. A biphasic liquid of stock solution nd oH 60 buffer was produced and the absorbance was then recorded and used to The process then reoeated

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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"seaas
The aim of this experiment was investigating and determining the effect of the pH of a
solution on the distribution coefficient of a drug, in this case benzoic acid. In order to carry
out this investigation, a pre-prepared 0.001998 mol dm stock solution of benzoic acid in
ethyl acetate was used to prepare standard solutions of varying concentrations whose
absorbances were measured to produce a calibration plot. A biphasic liquid of stock solution
and pH 6.0 buffer was produced and the absorbance was then recorded and used to
calculate the distribution coefficient of benzoic acid at this pH. The orocess then repeated,
using pH 7.0 buffer.
nt 70 buffer sotution
Transcribed Image Text:"seaas The aim of this experiment was investigating and determining the effect of the pH of a solution on the distribution coefficient of a drug, in this case benzoic acid. In order to carry out this investigation, a pre-prepared 0.001998 mol dm stock solution of benzoic acid in ethyl acetate was used to prepare standard solutions of varying concentrations whose absorbances were measured to produce a calibration plot. A biphasic liquid of stock solution and pH 6.0 buffer was produced and the absorbance was then recorded and used to calculate the distribution coefficient of benzoic acid at this pH. The orocess then repeated, using pH 7.0 buffer. nt 70 buffer sotution
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