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TASK 3: A pharmaceutical product is being scaled up from a pilot-scale mixer granulator with a batch size of 10 kg to a full-scale mixer granulator with a 40 kg batch size. (a) In the pilot-scale mixer, 2 kg isopropanol is added to the mixer over 15 min through a nozzle producing 300 µm diameter spray drops across a 0.25 m wide spray. Powder velocity in the spray zone is currently 0.2 m/s at pilot scale. Calculate the dimensionless spray flux at pilot-scale. (b) During scale-up, the ratio of liquid to dry powder is kept constant but the isopropanol flow rate is increased to maintain constant spray time. The new nozzle produces 500 µm drops over a 0.4 m wide spray zone. At full-scale, the powder velocity is 0.15 m/s. Calculate the new dimensionless spray flux at full-scale.

TASK 3: A pharmaceutical product is being scaled up from a pilot-scale mixer granulator with a batch size of 10 kg to a full-scale mixer granulator with a 40 kg batch size. (a) In the pilot-scale mixer, 2 kg isopropanol is added to the mixer over 15 min through a nozzle producing 300 µm diameter spray drops across a 0.25 m wide spray. Powder velocity in the spray zone is currently 0.2 m/s at pilot scale. Calculate the dimensionless spray flux at pilot-scale. (b) During scale-up, the ratio of liquid to dry powder is kept constant but the isopropanol flow rate is increased to maintain constant spray time. The new nozzle produces 500 µm drops over a 0.4 m wide spray zone. At full-scale, the powder velocity is 0.15 m/s. Calculate the new dimensionless spray flux at full-scale.

Introduction to Chemical Engineering Thermodynamics
Introduction to Chemical Engineering Thermodynamics
8th Edition
ISBN:9781259696527
Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart
Chapter1: Introduction
Section: Chapter Questions
Problem 1.1P
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ANSWERS =

a) 0.28

b) 0.57

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TASK 3: A pharmaceutical product is being scaled up from a pilot-scale mixer granulator with a batch size of 10 kg to a full-scale mixer granulator with a 40 kg batch size. (a) In the pilot-scale mixer, 2 kg isopropanol is added to the mixer over 15 min through a nozzle producing 300 µm diameter spray drops across a 0.25 m wide spray. Powder velocity in the spray zone is currently 0.2 m/s at pilot scale. Calculate the dimensionless spray flux at pilot-scale. (b) During scale-up, the ratio of liquid to dry powder is kept constant but the isopropanol flow rate is increased to maintain constant spray time. The new nozzle produces 500 µm drops over a 0.4 m wide spray zone. At full-scale, the powder velocity is 0.15 m/s. Calculate the new dimensionless spray flux at full-scale.
Transcribed Image Text:TASK 3: A pharmaceutical product is being scaled up from a pilot-scale mixer granulator with a batch size of 10 kg to a full-scale mixer granulator with a 40 kg batch size. (a) In the pilot-scale mixer, 2 kg isopropanol is added to the mixer over 15 min through a nozzle producing 300 µm diameter spray drops across a 0.25 m wide spray. Powder velocity in the spray zone is currently 0.2 m/s at pilot scale. Calculate the dimensionless spray flux at pilot-scale. (b) During scale-up, the ratio of liquid to dry powder is kept constant but the isopropanol flow rate is increased to maintain constant spray time. The new nozzle produces 500 µm drops over a 0.4 m wide spray zone. At full-scale, the powder velocity is 0.15 m/s. Calculate the new dimensionless spray flux at full-scale.
● ● a' Spray flux, Va, is a dimensionless measure of the density of drops falling on the powder surface given as follows: Ya = Va 30 2vswsda Where Q is the solution volumetric flow rate, v is the powder velocity in the spray zone, d is the average drop diameter and w, is the width of the spray
Transcribed Image Text:● ● a' Spray flux, Va, is a dimensionless measure of the density of drops falling on the powder surface given as follows: Ya = Va 30 2vswsda Where Q is the solution volumetric flow rate, v is the powder velocity in the spray zone, d is the average drop diameter and w, is the width of the spray
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