target molecule. Begin with the labeled starting material and be sure to include the synthetic equivalent (SE-1) in your synthesis. Target Molecule EtO₂C SE-1 CO₂Et EtO₂C CO₂Et Starting Material
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- Following is a synthesis for toremifene, a nonsteroidal estrogen antagonist whose structure is closely related to that of tamoxifen. (a) This synthesis makes use of two blocking groups, the benzyl (Bn) group and the tetrahydropyranyl (THP) group. Draw a structural formula of each group and describe the experimental conditions under which it is attached and removed. (b) Discuss the chemical logic behind the use of each blocking group in this synthesis. (c) Propose a mechanism for the conversion of D to E. (d) Propose a mechanism for the conversion of F to toremifene. (e) Is toremifene chiral? If so, which of the possible stereoisomers are formed in this synthesis?NOC XT Ph CH₂ Both primary and secondary amines add to a ß-unsaturated aldehydes and ketones to yield ß-amino aldehydes and ketones rather than the alternative imines. Under typical reaction conditions, both direct and conjugate modes of addition occur rapidly. But because the reactions are reversible, they generally proceed with thermodynamic control rather than kinetic control so the more stable conjugate addition product is often obtained to the complete exclusion of the less stable direct addition product. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions H H CH3NH₂ CH3 H-A :A Ph NHCH3 вон CH3 :A H-A 8bThe synthesis of the following compound involves the use of an epoxide. Describe the retrosynthetic analysis of the following antihistamine drug compound through a 1,1, 1,2, or 1,3-diX disconnect. Describe the stages of analysis and synthesis.
- 3. Propose a retrosynthetic analysis for the following target molecules and the corresponding forward syntheses. TM-1 TM-3propose a retrosynthetic analysis for the following molecules CI H3Ç Но 4-chloro-6-methoxyquinazolin-7-ol .cOOMe Но methyl 4-hydroxy-3-methoxybenzoateO NaBH4 Synthesis #2: Select a different set of two substrates and one reagent that could be combined to prepare benzphetamine. tymen Ph Ph Ph Ph NH Ph H O NaBH3CN, H+ 20= ano [H*], NaBH-CN Nucleophile
- The following scheme shows the retrosynthetic analysis of 1-isopentylaziridine to formseries of intermediates via Functional Group Inversion (FGI). Choose the correct reagentsof N-S for the respective conversion from the given list of reagents.The 1H- and 13C-NMR data of an ester of molecular formula C6H10O2 are given below. Also shown are the COSY and HETCOR NMR spectra of the ester. Draw the structure of the ester, explaining how you reach your conclusion. 1H-NMR: 7.20-6.90 (1H), 5.85 (1H), 4.16 (2H), 1.88 (3H), 1.31 (3H) ppm 13C-NMR: 166.7, 144.5, 123.0 , 60.2, 18.0, 14.3 ppmDraw the structure of a molecule that could be converted to cocaine via reductive amination. H+ NaBH3CN cocaine IMG_20220605_044753.jpg You 3 seconds ago Please explain the mechanism with steps
- Following is a retrosynthetic analysis for the synthesis of the herbicide (S)-Metolachlor from 2-ethyl-6-methylaniline, chloroacetic acid, acetone, and methanol. CI OMe OMe OMe 'N' HN N CI. + НО, Chloroacetic acid (S)-Metolachlor 3 NH2 CI + MEOH OMe Acetone Methanol 2-Ethyl-6-methylaniline Show reagents and experimental conditions for the synthesis of Metolachlor from these four organic starting materials. Your synthesis will most likely give a racemic mixture. The chiral catalyst used by Novartis for reduction in Step 2 gives 80% enantiomeric excess of the S enantiomer.Reset Help N-Acetylserotonin to melatonin Serotonin to N-acetylserotonin 5-Hydroxytryptophan to serotonin Acetylation Methylation Decarboxylation Submit Request Answer P Pearson Copyright © 2021 Pearson Education Inc. All rights reserved. Terms of Use | Privacy Policy | Permissions Contact Us / Clae17-14 There are three steps in Somfai's short synthesis of the alkaloid, stemoamide. Supply the missing reagents and products in this three-reaction sequence in the middle of the synthesis. 1)1-B: BrZnCH,CO,Et Grubbs-Il R 2) HOAC (PhyP)aPd CH2CI2 CHigINO THF-DMPU, A CisHz3NO3 C13H19NO3 Reference: J. Org. Chem. 2007, 72, 4246.