Table 27.2 pK, Values for lonizable Groups of Amino Acids pK of a-COOH pK, of a-NH, pK, of Side Chain Isoelectric Amino Acid Point (pl) Alanine 2.35 9.87 6.11 Arginine 2.01 9.04 12.48 10.76 Asparagine 2.02 8.80 5.41 Aspartic acid 2.10 9.82 3.86 2.98 Cysteine 2.05 10.25 8.00 5.02 Glutamic acid 2.10 9.47 4.07 3.08 Glutamine 2.17 9.13 5.65 - Glycine 2.35 9.78 6.06 - Histidine 1.77 9.18 6.10 7.64 Isoleucine 2.32 9.76 6.04 Leucine 2.33 9.74 6.04 Lysine 2.18 8.95 10.53 9.74 Methionine 2.28 9.21 5.74 Phenylalanine 2.58 9.24 5.91 Proline 2.00 10.60 6.30 Serine 2.21 9.15 5.68 Threonine 2.09 9.10 5.60 Tryptophan 2.38 9.39 5.88 Tyrosine 2.20 9.11 10.07 5.63 Valine 2.29 9.72 6.00

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Write the form of aspartic acid most prevalent at pH 1.0 and then show its reaction with the following. Consult Table 27.2 for pKa values of the ionizable groups in aspartic acid.

Q.) 1 mol NaOH

Table 27.2
pK, Values for lonizable Groups of Amino Acids
pK of
a-COOH
pK, of
a-NH,
pK, of
Side Chain
Isoelectric
Amino Acid
Point (pl)
Alanine
2.35
9.87
6.11
Arginine
2.01
9.04
12.48
10.76
Asparagine
2.02
8.80
5.41
Aspartic acid
2.10
9.82
3.86
2.98
Cysteine
2.05
10.25
8.00
5.02
Glutamic acid
2.10
9.47
4.07
3.08
Glutamine
2.17
9.13
5.65
-
Glycine
2.35
9.78
6.06
-
Histidine
1.77
9.18
6.10
7.64
Isoleucine
2.32
9.76
6.04
Leucine
2.33
9.74
6.04
Lysine
2.18
8.95
10.53
9.74
Methionine
2.28
9.21
5.74
Phenylalanine
2.58
9.24
5.91
Proline
2.00
10.60
6.30
Serine
2.21
9.15
5.68
Threonine
2.09
9.10
5.60
Tryptophan
2.38
9.39
5.88
Tyrosine
2.20
9.11
10.07
5.63
Valine
2.29
9.72
6.00
Transcribed Image Text:Table 27.2 pK, Values for lonizable Groups of Amino Acids pK of a-COOH pK, of a-NH, pK, of Side Chain Isoelectric Amino Acid Point (pl) Alanine 2.35 9.87 6.11 Arginine 2.01 9.04 12.48 10.76 Asparagine 2.02 8.80 5.41 Aspartic acid 2.10 9.82 3.86 2.98 Cysteine 2.05 10.25 8.00 5.02 Glutamic acid 2.10 9.47 4.07 3.08 Glutamine 2.17 9.13 5.65 - Glycine 2.35 9.78 6.06 - Histidine 1.77 9.18 6.10 7.64 Isoleucine 2.32 9.76 6.04 Leucine 2.33 9.74 6.04 Lysine 2.18 8.95 10.53 9.74 Methionine 2.28 9.21 5.74 Phenylalanine 2.58 9.24 5.91 Proline 2.00 10.60 6.30 Serine 2.21 9.15 5.68 Threonine 2.09 9.10 5.60 Tryptophan 2.38 9.39 5.88 Tyrosine 2.20 9.11 10.07 5.63 Valine 2.29 9.72 6.00
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