Find the pH of 0.1 M of the different form of histidine species. (See image attached)  b) What is the principal species at pH , pH 5, pH 8, and pH 11

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
icon
Concept explainers
Question

a) Find the pH of 0.1 M of the different form of histidine species. (See image attached) 

b) What is the principal species at pH , pH 5, pH 8, and pH 11?

**Histidine Ionization States and pKa Values**

The structural diagram on the left represents the amino acid histidine. The ionization process of histidine is depicted, showing the different protonation states and their corresponding pKa values:

1. **H₃His²⁺** → **H₂His⁺** 
   - **pKa₁ = 1.60**
   - This step involves the loss of a proton from the fully protonated form.

2. **H₂His⁺** → **HHis** 
   - **pKa₂ = 5.97**
   - In this step, a second proton is lost, resulting in a neutral species.

3. **HHis** → **His⁻** 
   - **pKa₃ = 9.28**
   - The final deprotonation leads to the negatively charged form of histidine.

The diagrams and notations depict how histidine transitions through these ionization states, highlighting key pKa values indicating the pH at which each protonation change occurs.
Transcribed Image Text:**Histidine Ionization States and pKa Values** The structural diagram on the left represents the amino acid histidine. The ionization process of histidine is depicted, showing the different protonation states and their corresponding pKa values: 1. **H₃His²⁺** → **H₂His⁺** - **pKa₁ = 1.60** - This step involves the loss of a proton from the fully protonated form. 2. **H₂His⁺** → **HHis** - **pKa₂ = 5.97** - In this step, a second proton is lost, resulting in a neutral species. 3. **HHis** → **His⁻** - **pKa₃ = 9.28** - The final deprotonation leads to the negatively charged form of histidine. The diagrams and notations depict how histidine transitions through these ionization states, highlighting key pKa values indicating the pH at which each protonation change occurs.
Expert Solution
steps

Step by step

Solved in 2 steps with 1 images

Blurred answer
Knowledge Booster
Ionic Equilibrium
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY