Synthesize the following ether from any two alcohols. YOU MUST SHOW the complete retrosynthetic analysis as well as the reagents you would use in the forward direction.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
synthesis of ether from alkylhalide and alkoxide ion is aceed williamson etherification
To do retrosynthesis, given ether first breaks into alkylbromide and alcohol by treating with HBr
From retrosynthesis it is cleared that, to synthesize the given ether the strarting materials used are butan-1-ol and 2-bromopropane.
But the condition is two starting materials are alcohols only.
Hence 2-bromopropane can be prepared from 2-propanol by treating with PBr3 through SN2 mechanism
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