Synthesis of Aspirin (Virtual Lab Only) Objective: Synthesis of Aspirin by esterification process. H2SO, HO. 50-60 °C, 15 min ÓH acetylsalicylic acid (2-Ethanoyloxybenzene carboxylic acid) (Aspirin) salicylic acid acetic anhydride (2-Hydroxybenzoic acid) (Ethanoic anhydride) Figure 1: Synthesis of Acetylsalicylic Acid (Aspirin) Table 1: Table of Physical Constants Compound Mass (g) n (moles) m.p. (°C) k.p. (°C) Density (g/mL) Molecular MW Volume Formula (mL) 2-Hydroxybenzoic CH6O3 138 5.00 0.0362 acid Ethanoic Anhydride C4H6O3 102 18.0 0.1765 Sulfuric acid H2SO4 Water H2O Aspirin Ref. Complete the Table of Physical Constants and provide reference(s) for the data

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Synthesis of Aspirin (Virtual Lab Only)
Objective: Synthesis of Aspirin by esterification proces.
H2SO4
OH
50-60 °C, 15 min
acetylsalicylic acid
(2-Ethanoyloxybenzene carboxylic acid)
(Aspirin)
salicylic acid
acetic anhydnde
(2-Hydroxybenzoic acid) (Ethanoic anhydride)
Figure 1: Synthesis of Acetylsalicylic Acid (Aspirin)
Table 1: Table of Physical Constants
Compound
Volume
Mass (g)
n (moles)
Density
(g/mL)
Molecular
MW
m.R. (*C) b.P. (°C)
Formula
(g/mol)
(mL)
2-Hydroxybenzoic
CH6O3
138
5.00
0.0362
acid
Ethanoic Anhydride
CH6O3
H2SO4
18.0
0.1765
102
Sulfuric acid
Water
H2O
Aspirin
Ref Complete the Table of Physical Constants and provide reference(s) for the data
Transcribed Image Text:Synthesis of Aspirin (Virtual Lab Only) Objective: Synthesis of Aspirin by esterification proces. H2SO4 OH 50-60 °C, 15 min acetylsalicylic acid (2-Ethanoyloxybenzene carboxylic acid) (Aspirin) salicylic acid acetic anhydnde (2-Hydroxybenzoic acid) (Ethanoic anhydride) Figure 1: Synthesis of Acetylsalicylic Acid (Aspirin) Table 1: Table of Physical Constants Compound Volume Mass (g) n (moles) Density (g/mL) Molecular MW m.R. (*C) b.P. (°C) Formula (g/mol) (mL) 2-Hydroxybenzoic CH6O3 138 5.00 0.0362 acid Ethanoic Anhydride CH6O3 H2SO4 18.0 0.1765 102 Sulfuric acid Water H2O Aspirin Ref Complete the Table of Physical Constants and provide reference(s) for the data
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