Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and 11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28th Her sister, who married an unaffected man, has two affected sons and a normal daughter. You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD). Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation.
Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and 11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28th Her sister, who married an unaffected man, has two affected sons and a normal daughter. You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD). Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Suppose a couple brought to you their 8-year old boy with progressive muscle weakness, and difficulty in motor skills resulting to awkward manner of walking and running . The boy’s 15-year old sister and 11-year old brother appear to be unaffected. They have a normal father and a normal pregnant mother. The mother had a brother who died at 26 yrs. of age with similar findings that seemed to worsen with age. The mother also has a sister with the same findings but it only manifested during her 28th Her sister, who married an unaffected man, has two affected sons and a normal daughter. You suspect a diagnosis of Duchenne Muscular Dystrophy (DMD).
- Draw the pedigree of this family. Follow protocols in making a pedigree. Provide the genotype of all individuals in the pedigree. Please provide also the gene notation.
- What is the risk (probability) that the fetus is affected?
- Amniocentesis has to be performed in order to determine the sex of the fetus. What is the risk that the child will be affected if the fetus is female? If the fetus is male? Show solution Female: _________ Male: ________
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