A 31 year old woman consults her physicain because she is concerned about developing breast cancer. She is currently in good health and she has never had any breast disease. Her concern arises bacause her sister has just been diagnosed as having breast cancer and her mother died of breast cancer. a. How can one determ ine if the cancer in this family is likely to be a dominantly inherited predisposition? b. What is the wom an's cahnce of developing breast cancer?

A 31 year old woman consults her physicain because she is concerned about developing breast cancer. She is currently in good health and she has never had any breast disease. Her concern arises bacause her sister has just been diagnosed as having breast cancer and her mother died of breast cancer. a. How can one determ ine if the cancer in this family is likely to be a dominantly inherited predisposition? b. What is the wom an's cahnce of developing breast cancer?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 5QP: Achondroplasia is a rare dominant autosomal defect resulting in dwarfism. The unaffected brother of...

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Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?
12. A. B. C. A certain type of migraine headache (M) is dominant to no migraines (m). What is the genotype of a man who has migraine headaches if his father did not have them? What is the genotype of a man who has migraine headaches if his mother did not have them? If a woman without migraines marries a man who is heterozygous for migraines, what would you expect for the genotypes and phenotypes of their children? If two people who are heterozygous for migraines marry and have children, what would you expect for the genotypes and phenotypes of the children.
Huntington’s disease, is an incurable neurodegenerative genetic disorder that affectsmuscle coordination and some cognitive functions, typically becoming noticeable inmiddle age. It results from an autosomal dominant gene (H) and there are no carriers ofthe disease. Two parents with Huntington’s disease have an affected child. What is theprobability that their next child will be an unaffected girl if they are not double-dominant?
6. A man with X-linked colorblindness marries a woman with no history of ibba colorblindness in her family. The daughter of this couple marries a normal man noitenmot and ended up hone daughter, and their daughter also marries a normal man. This mont blast couple has already had a child with color blindness. do sri ni novig A) What is the chance that next child will be color blind? B) What is the chance that this last couple will have an affected daughter? (d #50x²50 (
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In individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor recessive gene. If 2 normal parents had a daughter with the symptoms ofthis disease, and a normal son, what is the probability that he might be acarrier of the recessive gene?Express answer in fraction form.
An individual with 46, XX genotype is diagnosed with Duchenne-type Muscular Dystrophy, a recessive X-linked disorder. Genetic tests confirm that this individual is a heterozygote for this disorder. Briefly, but specifically, explain how it’s possible that they are showing symptoms of this disorder.
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A woman homozygous for normal height, with freckles, almond-shaped eyes, small nose, and Type A blood, has a Type O mother with no freckles and a type AB father with round eyes. She is engaged to a man with achondroplasia, round eyes and medium sized nose. Unlike his father, hismother is of normal height. Both his parents have Type O blood but nobody from both sides of his family has or had freckles. a. Write the COMPLETE genotypes of the man and the woman. Clearly indicate which genotype belongs to whom. b. Based on their genotypes, what is the probability that they will have: b.1 a child with Achondroplasia? b.2 a child of normal height? b.3 a child with type AB blood? b.4 a daughter with round eyes, freckles, and medium sized nose? b.5 a son with almond eyes, no freckles, and small nose?b.6 a daughter with same genotype as the woman? b.7 a son with same genotype as the man?
.Certain forms of human color blindness are inherited as X-linkedrecessive traits. Hemizygous males are color-blind, but heterozygous females are not. However, heterozygous females sometimeshave partial color blindness.A. Discuss why heterozygous females may have partial color blindness.B. Doctors identified an unusual case in which a heterozygousfemale was color-blind in her right eye but had normal colorvision in her left eye. Explain how this might have occurred.
. Assuming no involvement of the Bombay phenotype(in case you’ve already read ahead to Section 3.2):a. If a girl has blood type O, what could be the genotypes and corresponding phenotypes of her parents?b. If a girl has blood type B and her mother has bloodtype A, what genotype(s) and correspondingphenotype(s) could the other parent have?c. If a girl has blood type AB and her mother is alsoAB, what are the genotype(s) and correspondingphenotype(s) of any male who could not be thegirl’s father?
Sickle cell anemia is inherited as an autosomal recessive condition. It also exhibits incomplete dominance in that the heterozygous genotype displays a mild form of the disease known as sickle cell trait while individuals with the homozygous recessive genotype have a severe form of SCA. A man who has severe sickle cell anemia marries a woman who suffers from a mild trait. What is the probabilitu they will have a child with severe SCA?What is the probability they will have a child with mild SCA? What is the probability they will have a normal child? Show ALL work using punnett squares.