Starting with benzene and using any other reagents of your choice, design a synthesis for the following compound: OMe NO₂ Br Shown here is one possible synthetic pathway: A Part 1 Reagent(s) Part 1 Reagent(s): Part 2 Reagent(s): EH Cl₂, AICI, ADF NaOH, 350°C The transformations above can be performed with some reagent or combination of the reagents listed below. Give the necess reagents for each part in the correct order, as a string of letters (without spaces or punctuation, such as "EBF). If there is more one correct solution, provide just one answer. B OMe AICI, G Part 2 Reagent(s) Mel Br HCI, Zn OMe xs Br₂, AlBra NO₂ D Br I Mel, AlCl3 KMnO4, NaOH, heat (followed by H₂O* workup) E HNO₂, H₂SO4 AlBrs

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter16: Aldehydes And Ketones
Section: Chapter Questions
Problem 16.60P
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Starting with benzene and using any other reagents of your choice, design a synthesis for the following compound:
OMe
NO₂
Shown here is one possible synthetic pathway:
Br
A
F
Part 1
Reagent(s)
Part 1 Reagent(s): ADF
Part 2 Reagent(s): EH
Cl₂, AICI
The transformations above can be performed with some reagent or combination of the reagents listed below. Give the necessary
reagents for each part in the correct order, as a string of letters (without spaces or punctuation, such as "EBF). If there is more than
one correct solution, provide just one answer.
NaOH, 350°C
B
OMe
AICI3
G
Part 2
Reagent(s)
Mel
H
Br
HCI, Zn
OMe
xs Br₂, AlBr3
NO₂
D
Br
I
Mel, AlCl3
KMnO4, NaOH, heat
(followed by
H₂O* workup)
E
HNO₂, H₂SO4
AlBrs
Transcribed Image Text:Starting with benzene and using any other reagents of your choice, design a synthesis for the following compound: OMe NO₂ Shown here is one possible synthetic pathway: Br A F Part 1 Reagent(s) Part 1 Reagent(s): ADF Part 2 Reagent(s): EH Cl₂, AICI The transformations above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents for each part in the correct order, as a string of letters (without spaces or punctuation, such as "EBF). If there is more than one correct solution, provide just one answer. NaOH, 350°C B OMe AICI3 G Part 2 Reagent(s) Mel H Br HCI, Zn OMe xs Br₂, AlBr3 NO₂ D Br I Mel, AlCl3 KMnO4, NaOH, heat (followed by H₂O* workup) E HNO₂, H₂SO4 AlBrs
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