Solid Dosage Manufacturing FacilityFacility Description:The new facility will be constructed in Shanghai, China. The facility will be located in an industrial park area that will provide potable water, waste water and electrical services to the facility. All other utilities will need to be generated at the facility. The facility will need to support the existing product line described above. It will also need to provide an additional 25% capacity across all unit operations. The layout and the overall architecture need to support the additional capacity. The equipment will not be purchased initially for the additional capacity. The utility design should consider alternative approaches to support additional capacity at a later date if possible.The site will be sending the tablets and capsules to another facility for packaging so do not include packaging facility design, but include the intermediate storage and transportation requirement to the packaging facility in Brussels, Belgium for EU market.Assume facility operates 7 days a week and 24 hours per day with three shifts. Class Project: Solid Dosage Manufacturing FacilityProduct Description:This facility will be making five products; 3 tablets and two capsulesCharacteristicsTablet 1Tablet 2Tablet 3Capsule 1Capsule 2ActiveABAIngredientProduct20 mg40 mg10 mg30 mg10 mgConfigurationVolume500 million/yr300million/yr800 million/yr300 million/yr600 million/yrGranulationWetWetDryNANAProcess10000 per10000 per10000 per5000 per hour5000 per hourTabletPress/Capsule hourFilling SpeedhourhourNoNANAYesTablet Coating YesProcess Description:Tablet 1 and 2DISPENSINGRAWMATERIALSVISUALINSPECTIONWETCOMPRESSTABLETCOATMILLBLENDGRANULATETablet 3 DISPENSINGRAWMATERIALSDRYBLENDMATERIALSGRANULATEBLENDCOMPRESSTABLETCOATVISUALINSPECTIONCapsule 1 and 2DISPENSINGBLENDMATERIALSCAPSULERAWMATERIALSCAPSULEPOLISHINGVISUALINSPECTIONFILLFacility Description:The new facility will be constructed in Shanghai, China. The facility will be located in an industrial parkarea that will provide potable water, waste water and electrical services to the facility. All other utilitieswill need to be generated at the facility.The facility will need to support the existing product line described above. It will also need to provide anadditional 25% capacity across all unit operations. The layout and the overall architecture need tosupport the additional capacity. The equipment will not be purchased initially for the additionalcapacity. The utility design should consider alternative approaches to support additional capacity at alater date if possible.The site will be sending the tablets and capsules to another facility for packaging so do not includepackaging facility design, but include the intermediate storage and transportation requirement to thepackaging facility in Brussels, Belgium for EU market.Assume facility operates 7 days a week and 24 hours per day with three shifts.

Given Description of a new solid dosage facility to be constructed that needs to generate all of…

Answered: Solid Dosage Manufacturing Facility…

Introduction to Chemical Engineering Thermodynamics

8th Edition

ISBN:9781259696527

Author:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart

Publisher:J.M. Smith Termodinamica en ingenieria quimica, Hendrick C Van Ness, Michael Abbott, Mark Swihart

Chapter1: Introduction

Section: Chapter Questions

Problem 1.1P

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Solid Dosage Manufacturing Facility

Facility Description:

The new facility will be constructed in Shanghai, China. The facility will be located in an industrial park area that will provide potable water, waste water and electrical services to the facility. All other utilities will need to be generated at the facility.

The facility will need to support the existing product line described above. It will also need to provide an additional 25% capacity across all unit operations. The layout and the overall architecture need to support the additional capacity. The equipment will not be purchased initially for the additional capacity. The utility design should consider alternative approaches to support additional capacity at a later date if possible.

The site will be sending the tablets and capsules to another facility for packaging so do not include packaging facility design, but include the intermediate storage and transportation requirement to the packaging facility in Brussels, Belgium for EU market.

Assume facility operates 7 days a week and 24 hours per day with three shifts.

Class Project: Solid Dosage Manufacturing Facility
Product Description:
This facility will be making five products; 3 tablets and two capsules
Characteristics
Tablet 1
Tablet 2
Tablet 3
Capsule 1
Capsule 2
Active
A
B
A
Ingredient
Product
20 mg
40 mg
10 mg
30 mg
10 mg
Configuration
Volume
500 million/yr
300million/yr
800 million/yr
300 million/yr
600 million/yr
Granulation
Wet
Wet
Dry
NA
NA
Process
10000 per
10000 per
10000 per
5000 per hour
5000 per hour
Tablet
Press/Capsule hour
Filling Speed
hour
hour
No
NA
NA
Yes
Tablet Coating Yes
Process Description:
Tablet 1 and 2
DISPENSING
RAW
MATERIALS
VISUAL
INSPECTION
WET
COMPRESS
TABLET
COAT
MILL
BLEND
GRANULATE
Tablet 3

DISPENSING
RAW
MATERIALS
DRY
BLEND
MATERIALS
GRANULATE
BLEND
COMPRESS
TABLET
COAT
VISUAL
INSPECTION
Capsule 1 and 2
DISPENSING
BLEND
MATERIALS
CAPSULE
RAW
MATERIALS
CAPSULE
POLISHING
VISUAL
INSPECTION
FILL
Facility Description:
The new facility will be constructed in Shanghai, China. The facility will be located in an industrial park
area that will provide potable water, waste water and electrical services to the facility. All other utilities
will need to be generated at the facility.
The facility will need to support the existing product line described above. It will also need to provide an
additional 25% capacity across all unit operations. The layout and the overall architecture need to
support the additional capacity. The equipment will not be purchased initially for the additional
capacity. The utility design should consider alternative approaches to support additional capacity at a
later date if possible.
The site will be sending the tablets and capsules to another facility for packaging so do not include
packaging facility design, but include the intermediate storage and transportation requirement to the
packaging facility in Brussels, Belgium for EU market.
Assume facility operates 7 days a week and 24 hours per day with three shifts.

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