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Sister chromatids Treat cells with agents that make them swell and fixes them onto slide. Denature chromosomal DNA Denatured- DNA Add single-stranded DNA probes that have blotin Incorporated Into them. Hybridized probe Add fluorescently labeled avidin that binds to blotin. Fluorescent Fluorescent - molecule bound to probe question and your understanding of the topic? From the question, you know that some people with PKU have a point mutation in the phenylalanine hydrox ylase gene, whereas others have experienced a deletion of the gene. From your understanding of the topic, you may remember that FISH is used to detect a gene's location within an intact set of chromosomes. PROBLEM-SOLVING S TRATEGY: Design an experiment. One strategy to solve this problem is to design an experiment using FISH. View with a fluorescence FIGURE 23.2 The technique of fluorescence in situ hybridization (FISH). The probe hybridizes to the denatured chromosomal DNA only at a specific mlcroscope. ONLINE ANIMATION complementary site in the genome. Note that the chromosomes are highly condensed metaphase chromosomes that have already replicated. These are sister chromatids. Therefore, each X- shaped chromosome actually contains two copies of a particular gene. Because the sister chromatids are identical, a probe that recognizes a site on one sister chromatid will also bind to the same site on the other. CONCEPT CHECK: Why does the probe bind to a specific site on a chromosome?

Sister chromatids Treat cells with agents that make them swell and fixes them onto slide. Denature chromosomal DNA Denatured- DNA Add single-stranded DNA probes that have blotin Incorporated Into them. Hybridized probe Add fluorescently labeled avidin that binds to blotin. Fluorescent Fluorescent - molecule bound to probe question and your understanding of the topic? From the question, you know that some people with PKU have a point mutation in the phenylalanine hydrox ylase gene, whereas others have experienced a deletion of the gene. From your understanding of the topic, you may remember that FISH is used to detect a gene's location within an intact set of chromosomes. PROBLEM-SOLVING S TRATEGY: Design an experiment. One strategy to solve this problem is to design an experiment using FISH. View with a fluorescence FIGURE 23.2 The technique of fluorescence in situ hybridization (FISH). The probe hybridizes to the denatured chromosomal DNA only at a specific mlcroscope. ONLINE ANIMATION complementary site in the genome. Note that the chromosomes are highly condensed metaphase chromosomes that have already replicated. These are sister chromatids. Therefore, each X- shaped chromosome actually contains two copies of a particular gene. Because the sister chromatids are identical, a probe that recognizes a site on one sister chromatid will also bind to the same site on the other. CONCEPT CHECK: Why does the probe bind to a specific site on a chromosome?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Why does the probe bind to a specific site on a chromosome?

Sister chromatids Treat cells with agents that make them swell and fixes them onto slide. Denature chromosomal DNA Denatured- DNA Add single-stranded DNA probes that have blotin Incorporated Into them. Hybridized probe Add fluorescently labeled avidin that binds to blotin. Fluorescent
Transcribed Image Text:Sister chromatids Treat cells with agents that make them swell and fixes them onto slide. Denature chromosomal DNA Denatured- DNA Add single-stranded DNA probes that have blotin Incorporated Into them. Hybridized probe Add fluorescently labeled avidin that binds to blotin. Fluorescent
Fluorescent - molecule bound to probe question and your understanding of the topic? From the question, you know that some people with PKU have a point mutation in the phenylalanine hydrox ylase gene, whereas others have experienced a deletion of the gene. From your understanding of the topic, you may remember that FISH is used to detect a gene's location within an intact set of chromosomes. PROBLEM-SOLVING S TRATEGY: Design an experiment. One strategy to solve this problem is to design an experiment using FISH. View with a fluorescence FIGURE 23.2 The technique of fluorescence in situ hybridization (FISH). The probe hybridizes to the denatured chromosomal DNA only at a specific mlcroscope. ONLINE ANIMATION complementary site in the genome. Note that the chromosomes are highly condensed metaphase chromosomes that have already replicated. These are sister chromatids. Therefore, each X- shaped chromosome actually contains two copies of a particular gene. Because the sister chromatids are identical, a probe that recognizes a site on one sister chromatid will also bind to the same site on the other. CONCEPT CHECK: Why does the probe bind to a specific site on a chromosome?
Transcribed Image Text:Fluorescent - molecule bound to probe question and your understanding of the topic? From the question, you know that some people with PKU have a point mutation in the phenylalanine hydrox ylase gene, whereas others have experienced a deletion of the gene. From your understanding of the topic, you may remember that FISH is used to detect a gene's location within an intact set of chromosomes. PROBLEM-SOLVING S TRATEGY: Design an experiment. One strategy to solve this problem is to design an experiment using FISH. View with a fluorescence FIGURE 23.2 The technique of fluorescence in situ hybridization (FISH). The probe hybridizes to the denatured chromosomal DNA only at a specific mlcroscope. ONLINE ANIMATION complementary site in the genome. Note that the chromosomes are highly condensed metaphase chromosomes that have already replicated. These are sister chromatids. Therefore, each X- shaped chromosome actually contains two copies of a particular gene. Because the sister chromatids are identical, a probe that recognizes a site on one sister chromatid will also bind to the same site on the other. CONCEPT CHECK: Why does the probe bind to a specific site on a chromosome?
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