Sickle cell disease (SCD) is a group of inherited disorders. People with SCD have sickle-shaped red blood cells. A single base substitution mutation can cause one type of SCD. This mutation causes a change in the structure of the beta polypeptide chains in haemoglobin. Explain how a single base substitution causes a change in the structure of this polypeptide.

Sickle cell disease (SCD) is a group of inherited disorders. People with SCD have sickle-shaped red blood cells. A single base substitution mutation can cause one type of SCD. This mutation causes a change in the structure of the beta polypeptide chains in haemoglobin. Explain how a single base substitution causes a change in the structure of this polypeptide.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 20QP: If an extra nucleotide is inserted in the first exon of the beta globin gene, what effect will it...

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Sickle cell disease (SCD) is a group of inherited disorders. People with SCD have
sickle-shaped red blood cells. A single base substitution mutation can cause one type
of SCD. This mutation causes a change in the structure of the beta polypeptide
chains in haemoglobin.
Explain how a single base substitution causes a change in the structure of this
polypeptide.
Do not include details of transcription and translation in your answer.

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