Shown below is a possible synthesis of the target molecule, starting with a substrate containing two carbon atoms: Å 1) A The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. bak H 2) H3O* E PBr3 ? t-BUOK B 1) Å 2) H3O* Mg F Ph3P=CH2 NH₂OH [H] - H₂O HO. HO с OH + acid G PCC or DMP K Na2Cr₂O7, H₂SO4, H₂O NaOEt D H 1) CH3CH₂MgBr; 2) H3O* L 1) CH3MgBr; 2) H3O+
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Give the neccessary reagents in the correct order, as a string of letters.
![Shown below is a possible synthesis of the target molecule, starting with a substrate containing two carbon atoms:
Å
1)
A
The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary
reagents in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct
solution, provide just one answer.
bak
H
2) H3O*
E
PBr3
?
t-BUOK
B
1) Å
2) H3O*
Mg
F
Ph3P=CH2
NH₂OH
[H]
- H₂O
HO.
HO
с
OH + acid
G
PCC or DMP
K
Na2Cr₂O7, H₂SO4, H₂O
NaOEt
D
H
1) CH3CH₂MgBr;
2) H3O*
L
1) CH3MgBr;
2) H3O+](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9156f8b7-4f51-47ca-9489-d1b49d440928%2F17c0673f-44a9-4fff-9432-54cbb304c6c1%2Fv5prq2i_processed.png&w=3840&q=75)
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