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Show how you would prepare 4-deuterio toluene from toluene.

Show how you would prepare 4-deuterio toluene from toluene.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Solvent choice: When we write reactions on paper, we usually specify a solvent that is commonly used for the particular reaction. However, until we go into the laboratory and try the reactions, the solvent effects will not be entirely known. In the case of a Grignard reaction, we need to choose a solvent that will not react with the highly reactive reagent. Of course, any protic solvent such as water or alcohols or acetic acid are unacceptable as they will destroy the Grignard reagent through protonation. Although we generally do not wish to destroy our Grignard reagent, this protonation by water can be used to specifically label molecules with isotopes such as deuterium or tritium. Show how you would prepare 4-deuterio toluene from toluene.
Transcribed Image Text:Solvent choice: When we write reactions on paper, we usually specify a solvent that is commonly used for the particular reaction. However, until we go into the laboratory and try the reactions, the solvent effects will not be entirely known. In the case of a Grignard reaction, we need to choose a solvent that will not react with the highly reactive reagent. Of course, any protic solvent such as water or alcohols or acetic acid are unacceptable as they will destroy the Grignard reagent through protonation. Although we generally do not wish to destroy our Grignard reagent, this protonation by water can be used to specifically label molecules with isotopes such as deuterium or tritium. Show how you would prepare 4-deuterio toluene from toluene.
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