Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![NaOH
Y
NINH,
H₂SO4, heat
1. (CH3)₂CO
2. H₂O*
0:0
OH
Problem 45 of 58
B
D
Lindlar's catalyst
NaOH
H₂SO4, heat
♡
Done
H₂
Pd/C](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1ba2f8b0-0e44-4073-8850-ce5b48deecdf%2Ff573c105-d99d-42b7-9fe3-8ded7e170c7c%2F9tizwhq_processed.jpeg&w=3840&q=75)
![this hydrohalogenation reaction. Include all lone pairs and charges
as appropriate.
Select to Draw
H₂O
Drawing
H3O*
H₂O
1,2-hydride
shift
HH
H
H
H
H
Select to Draw
a](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1ba2f8b0-0e44-4073-8850-ce5b48deecdf%2Ff573c105-d99d-42b7-9fe3-8ded7e170c7c%2F280q754_processed.jpeg&w=3840&q=75)
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