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Select the chemical consequences that could contribute to DNA instability at AP sites. fewer hydrogen bonds between the unpaired pyrimidine base and water disruption of the base-stacking interactions increased ability of the deoxyribose ring to open without the attachment of the purine base decreased interaction between the mutated DNA strand and histones

Select the chemical consequences that could contribute to DNA instability at AP sites. fewer hydrogen bonds between the unpaired pyrimidine base and water disruption of the base-stacking interactions increased ability of the deoxyribose ring to open without the attachment of the purine base decreased interaction between the mutated DNA strand and histones

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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It is more than one option for the answer. Not just "increased ability of the deoxyribose ring to open without the attachment of the purine base"

Select the chemical consequences that could contribute to DNA instability at AP sites. fewer hydrogen bonds between the unpaired pyrimidine base and water disruption of the base-stacking interactions increased ability of the deoxyribose ring to open without the attachment of the purine base decreased interaction between the mutated DNA strand and histones
Transcribed Image Text:Select the chemical consequences that could contribute to DNA instability at AP sites. fewer hydrogen bonds between the unpaired pyrimidine base and water disruption of the base-stacking interactions increased ability of the deoxyribose ring to open without the attachment of the purine base decreased interaction between the mutated DNA strand and histones
Hydrolysis of the N-glycosyl bond between deoxyribose and a purine base in DNA creates an apurinic (AP) site. An AP site is more thermodynamically destabilizing to a DNA molecule than is a mismatched base pair. Examine the structure of an AP site. HN H₂N N 0 Guanine -O-P-O-CH₂O. H₂N H HN H H H Hod H ofo -0- Guanosine residue (in DNA) -0-CH₂ H H H Apurinic residue H OH H
Transcribed Image Text:Hydrolysis of the N-glycosyl bond between deoxyribose and a purine base in DNA creates an apurinic (AP) site. An AP site is more thermodynamically destabilizing to a DNA molecule than is a mismatched base pair. Examine the structure of an AP site. HN H₂N N 0 Guanine -O-P-O-CH₂O. H₂N H HN H H H Hod H ofo -0- Guanosine residue (in DNA) -0-CH₂ H H H Apurinic residue H OH H
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