Select four (4) of the followings synthesis (A to F) to show the steps required to fo the specific product using Acetylene as starting reagent. Include the reagents neec to complete each step and the intermediate products. (Hint: Consider to use the r map chart for all the reactions cover until chapter 9 and draw a retrosynthesis anal to help you to find the appropriate steps in each synthesis.) CH3CH,CCH3 ÇI CH3CH2C=C-H CH3CH2C=CH2 CH3CH2CH3 A CH,CH2CH2C-H B CH3CH2 CH3
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![Select four (4) of the followings synthesis (A to F) to show the steps required to form
the specific product using Acetylene as starting reagent. Include the reagents need it
to complete each step and the intermediate products. (Hint: Consider to use the road
map chart for all the reactions cover until chapter 9 and drawa retrosynthesis analysis
to help you to find the appropriate steps in each synthesis.)
CH3CH2CCH3
CI
CH3CH2C=C-H
CH3CH2C=CH2
CH3CH2CH3
CH3CH2CH2Č-H
B
CH3CH2
CH3
C3D
C=C
CH3CH2CH2C=CH
D
ター
H.
H.
CH3
CH3CH2
G
CI
HC=CH
4-
H.
CH3
F
CI
CH»CH3
CH3CH2CCH2CH2CH3
CH3CH2CHCH»Br
OH
OH
CH3CH2CHCH2CH2CH3
CH3CH2C=CCH2CH3
CH3CH2C=CCH3
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