Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Tabl entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"?
Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Tabl entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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19,21

Transcribed Image Text:Disease Control
group group
Allele A 25,350
24,133
Allele C
Allele C 24,650 25,867 Allele T
SNP1
SNP 2; risk allele is C
SNP 3; risk allele is G
SNP 2; risk allele is T
SNP 3; risk allele is A
Results are shown above for 3 biallelic SNPs on the same chromosome used in a
GWAS examining SNP-trait correlations for a complex human disease trait. Table
entries show the number of people with the indicated SNP allele that have the
disease (disease group) or don't have the disease (control group). Which SNP
would have the highest -log₁0(p-value) score in a Manhattan plot summarizing
results of this GWAS, and which is the SNP "risk allele"?
SNP 1; risk allele is A
SNP2
SNP 1; risk allele is C
Disease
Control
group
group
1,420
1,509
48,580 48,491
SNP3
Allele G
Allele A
Disease Control
group group
47,360
3,109
2,640
46,891

Transcribed Image Text:A population has an inbreeding co-efficient of 0.9. Which of the following
statements is consistent with this information?
O
individuals in this population are homozygous for alleles of most genes
allelic variation for genes in this population is high
individuals in this population are heterozygous for alleles of most genes
random mating in the population is common
the population is in Hardy-Weinberg equilibrium
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