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Regulation of the Citric Acid Cycle

Regulation of the Citric Acid Cycle

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Regulation of the Citric Acid Cycle TCA regulation occurs at Steps 3 and Step 4. Regulation at the Isocitrate Dehydrogenase Complex (Step 3) ➤Inihibitors: NADH, ATP Why? ►Activators: ADP Why? Regulation at the a-Ketoglutarate Dehydrogenas Complex (Step 4) Inihbitors: NADH, Succinyl-CoA, ATP Activators: ADP Why? Why? Malate Succinate Dynaxe AceglCal Oulaceuse SacrilCal Inhibited by ATP acetyl-CoA and NADH Inhibited by ATP. NADIL saccialCal citrate X Carve bocitrate a-Kengharate X X Control points Inhibition of reaction Sep respiring electron accepton, either NAD or FAD Inhibited be ATP: NADH Stimulated by ADP, NAD lohibined be ATP, NADI, and scclot Department of Medical Technology, Biochemistry Cluster-2022-2023
Transcribed Image Text:Regulation of the Citric Acid Cycle TCA regulation occurs at Steps 3 and Step 4. Regulation at the Isocitrate Dehydrogenase Complex (Step 3) ➤Inihibitors: NADH, ATP Why? ►Activators: ADP Why? Regulation at the a-Ketoglutarate Dehydrogenas Complex (Step 4) Inihbitors: NADH, Succinyl-CoA, ATP Activators: ADP Why? Why? Malate Succinate Dynaxe AceglCal Oulaceuse SacrilCal Inhibited by ATP acetyl-CoA and NADH Inhibited by ATP. NADIL saccialCal citrate X Carve bocitrate a-Kengharate X X Control points Inhibition of reaction Sep respiring electron accepton, either NAD or FAD Inhibited be ATP: NADH Stimulated by ADP, NAD lohibined be ATP, NADI, and scclot Department of Medical Technology, Biochemistry Cluster-2022-2023
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