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- Determine and label the configuration of each chiral carbon in the molecule shown below. HN B O FI OH The molecule shown below is the synthetic drug Latuda (Lurasidone) that is prescribed for antipsychotic for the treatment of schizophrenia in adults and adolescents (13-17 years). Examine the molecule carefully and answer the following questions. H 'N (S) H INH (R) (S) (R) IH H (S) O (S) a) Identify and label the functional groups in the molecule. b) Confirm the configuration of each stereogenic (R/S) center the molecule. c) Label the hybridization of all the nitrogen atoms in the molecule d) Circle of the most basic atom in the molecule and estimate the pKa of the conjugate acid of the base.1.identify the presence of any chiral carbons in your structure by putting a star/highlighting at the appropriate carbon(s). If you have none explain why? 2. identify the presence of an anomeric carbons in your structure by putting a star/highlighting at the appropriate carbon(s). If you have none explain why?Identify each molecule as Chiral or Achiral and write the number of Asymmetric carbons present in each chiral molecules. T) 3 - Chloro- 2- butanol H- -HO- H- -HO- H- -HO- H- -OH ČH2OH U) V)
- Are the following compounds chiral ? Determine the configuration if it is chiral and draw the enantiomer, for each structure.2. Assign R and S configurations for each chiral center in the following compound. Draw enantiomers, diastereomers and clearly indicate them. CH3 H C CI Br CH3 H5. Assign R or S configuration to each chirality center in the following molecules: CH3 CH3 Br (a) Br (b) (c) HaCH3 HaBr H OH CH3 H3C H OH H CH3 OH Which of these compounds are enantiomers, and which are diastereomers?
