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- Redraw the following molecule and assign R or S configuration to each chirality center. CH₂OH HO H H OH HO H CH₂OHAssign R or S configuration to the chirality centers in the molecule below.Determine and label the configuration of each chiral carbon in the molecule shown below. HN B O FI OH The molecule shown below is the synthetic drug Latuda (Lurasidone) that is prescribed for antipsychotic for the treatment of schizophrenia in adults and adolescents (13-17 years). Examine the molecule carefully and answer the following questions. H 'N (S) H INH (R) (S) (R) IH H (S) O (S) a) Identify and label the functional groups in the molecule. b) Confirm the configuration of each stereogenic (R/S) center the molecule. c) Label the hybridization of all the nitrogen atoms in the molecule d) Circle of the most basic atom in the molecule and estimate the pKa of the conjugate acid of the base.
- 1.identify the presence of any chiral carbons in your structure by putting a star/highlighting at the appropriate carbon(s). If you have none explain why? 2. identify the presence of an anomeric carbons in your structure by putting a star/highlighting at the appropriate carbon(s). If you have none explain why?There are eight chirality centers in the following molecule. Identify each asymmetric carbon atom by clicking on the circled carbons that are chiral. HOHow many chirality centers does this molecule have?
- Consider the following compound and answer the questions below OH CO2H HO2C Он a) Draw a Fisher Projection for this compound. b) Is this compound chiral or achiral? Explain your answer.How to determine chirality?2. Assign R and S configurations for each chiral center in the following compound. Draw enantiomers, diastereomers and clearly indicate them. CH3 H C CI Br CH3 H
- 5. Assign R or S configuration to each chirality center in the following molecules: CH3 CH3 Br (a) Br (b) (c) HaCH3 HaBr H OH CH3 H3C H OH H CH3 OH Which of these compounds are enantiomers, and which are diastereomers?Determine if the following compounds are chiral or achiral. Put an "X" in the box for chiral and a "0" for achiral. H3C H H3C Br -Br H H₂C- H- H -Br -Br CH3 *** Br H- Br- HO COOH -H -OH -H COOH OHDetermine the absolute configuration of the following compounds anddraw the structure (Fischer projection) of the other enantiomer.
