reaction as a function of substrate concentration. Ex- plain why the maximal velocity can be represented by the expression
reaction as a function of substrate concentration. Ex- plain why the maximal velocity can be represented by the expression
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
![1. ( .
tion can be represented by the so-called Michaelis
equation
) The velocity of an enzyme catalyzed reac-
Vmax [S]
Vo =
Km
Vo =
max
kcat [Eo] [So]
(Км + [Sol)
V max
where [So] is the initial substrate concentration, [Eo]
is the total enzyme concentration, kcat is the cataly-
tic rate constant or turnover number, and KM repre-
sents the Michaelis constant. The graph on the
right illustrates the dependence of the velocity of the
reaction as a function of substrate concentration. Ex-
Km
[S] (mm)
plain why the maximal velocity can be represented
by the expression
Vmax = Kcat [Eo]
at very high substrate concentrations.
Vo (µm/min)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7e3218aa-1b65-42a2-9071-7edb43c3a555%2Fe538b930-bc9e-4b74-af3f-fb7952c406b6%2Fe3e3w1o_processed.png&w=3840&q=75)
Transcribed Image Text:1. ( .
tion can be represented by the so-called Michaelis
equation
) The velocity of an enzyme catalyzed reac-
Vmax [S]
Vo =
Km
Vo =
max
kcat [Eo] [So]
(Км + [Sol)
V max
where [So] is the initial substrate concentration, [Eo]
is the total enzyme concentration, kcat is the cataly-
tic rate constant or turnover number, and KM repre-
sents the Michaelis constant. The graph on the
right illustrates the dependence of the velocity of the
reaction as a function of substrate concentration. Ex-
Km
[S] (mm)
plain why the maximal velocity can be represented
by the expression
Vmax = Kcat [Eo]
at very high substrate concentrations.
Vo (µm/min)
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