Rank the reactivity of the compounds below toward nucleophilic acyl substitution by writing the compounds' letters in the proper blanks in the box below. HN. CI Br CH3 CH3 A C D E rank compounds for acyl substitution reactivity

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Chapter1: Chemical Foundations
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**Objective:** Rank the reactivity of the compounds below toward nucleophilic acyl substitution by writing the compounds' letters in the proper blanks in the box below.

**Compounds:**

- **Compound A:** Structure with a carbonyl group attached to an ester.
- **Compound B:** Structure with a carbonyl group attached to an amide (NH group).
- **Compound C:** Structure with a carbonyl group and a chlorine atom (acid chloride).
- **Compound D:** Structure with a carbonyl group attached to a ketone.
- **Compound E:** Structure with a carbonyl group and a bromine atom (bromo ketone).

**Task:** Place the letters of the compounds in the blanks provided according to their reactivity, from most reactive to least reactive:

\[ \_\_\_\_\_ \quad \_\_\_\_\_ \quad \_\_\_\_\_ \quad \_\_\_\_\_ \quad \_\_\_\_\_ \]

**Reactivity Scale:** 
- **Most reactive** 
- **Least reactive**

*Note:* Use your knowledge of organic chemistry to determine the reactivity order based on the functional groups present in each compound.
Transcribed Image Text:**Objective:** Rank the reactivity of the compounds below toward nucleophilic acyl substitution by writing the compounds' letters in the proper blanks in the box below. **Compounds:** - **Compound A:** Structure with a carbonyl group attached to an ester. - **Compound B:** Structure with a carbonyl group attached to an amide (NH group). - **Compound C:** Structure with a carbonyl group and a chlorine atom (acid chloride). - **Compound D:** Structure with a carbonyl group attached to a ketone. - **Compound E:** Structure with a carbonyl group and a bromine atom (bromo ketone). **Task:** Place the letters of the compounds in the blanks provided according to their reactivity, from most reactive to least reactive: \[ \_\_\_\_\_ \quad \_\_\_\_\_ \quad \_\_\_\_\_ \quad \_\_\_\_\_ \quad \_\_\_\_\_ \] **Reactivity Scale:** - **Most reactive** - **Least reactive** *Note:* Use your knowledge of organic chemistry to determine the reactivity order based on the functional groups present in each compound.
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