Questions 12-14: Results of a randomized clinical trial of a new vaccine formulated to protect against SARS CoV-2 infection are shown in the following table. A total of 100,000 adults who were negative for infection at baseline enrolled in the study. Estimates shown in the following table are based on results after follow-up of six months. SARS COV-2 SARS COV-2 Status Positive Total Subjects Negative Received Vaccine 10 49,990 50,000 Did not receive vaccine 200 49,810 50,000 4. What can you conclude if the Z score for these data is -7? O B. The vaccine significantly increased SARS CoV-2 infection. DA. The vaccine significantly reduced SARS COV-2 infection. O D. None of the above. o C. The vaccine had no effect.
Questions 12-14: Results of a randomized clinical trial of a new vaccine formulated to protect against SARS CoV-2 infection are shown in the following table. A total of 100,000 adults who were negative for infection at baseline enrolled in the study. Estimates shown in the following table are based on results after follow-up of six months. SARS COV-2 SARS COV-2 Status Positive Total Subjects Negative Received Vaccine 10 49,990 50,000 Did not receive vaccine 200 49,810 50,000 4. What can you conclude if the Z score for these data is -7? O B. The vaccine significantly increased SARS CoV-2 infection. DA. The vaccine significantly reduced SARS COV-2 infection. O D. None of the above. o C. The vaccine had no effect.
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
Transcribed Image Text:**Analysis of Clinical Trial Data for a SARS CoV-2 Vaccine**
The results displayed below are from a randomized clinical trial of a new vaccine designed to protect against SARS CoV-2 infection. A study was conducted with 100,000 adult participants who were initially negative for the infection. Results were collected after a six-month follow-up period. The outcomes are summarized in the table:
| Status | SARS CoV-2 Positive | SARS CoV-2 Negative | Total Subjects |
|-------------------------|---------------------|---------------------|----------------|
| **Received Vaccine** | 10 | 49,990 | 50,000 |
| **Did not receive vaccine** | 200 | 49,810 | 50,000 |
**Interpretation and Statistical Analysis**
1. **Vaccine Group**:
- Positive Cases: 10
- Negative Cases: 49,990
2. **Non-Vaccine Group**:
- Positive Cases: 200
- Negative Cases: 49,810
**Question for Evaluation**
What conclusion can be drawn if the Z score for these data is -7?
**Options**:
- **A.** The vaccine significantly reduced SARS CoV-2 infection.
- **B.** The vaccine significantly increased SARS CoV-2 infection.
- **C.** The vaccine had no effect.
- **D.** None of the above.
**Analysis**:
The Z score of -7 strongly suggests statistical significance in the reduction of SARS CoV-2 infections due to the vaccine. Therefore, the most appropriate conclusion is:
**A. The vaccine significantly reduced SARS CoV-2 infection.**
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