CO2 pyruvate Lactate Dehydrogenase CO2 lactate Of the following, which correctly indicates the metabolic cause of the player hypoglycemia? OA. Anaerobic exercise leads to an accumulation of lactic acid in the muscle, which is sent to the liver via the bloodstream. The liver will then convert the lactic acid to pyruvate via the enzyme lactate dehydrogenase, which consumes cytosolic NADH in the reaction. Pyruvate is then metabolized to glucose via the gluconeogenic pathway, and glucose is sent into the bloodstream for use by the other organs. Ethanol is processed by the liver via alcohol dehydrogenase. Alcohol dehydrogenase consumes cytosolic NADH to metabolize the ethanol. As a consequence, the pool of NADH available for lactate dehydrogenase is significantly reduced, thereby supressing the conversion of lactate to pyruvate and subsequent gluconeogenesis, thereby creating a state of hypoglycemia, presenting with the symptoms described. O B. Anaerobic exercise leads to an accumulation of lactic acid in the muscle, which is sent to the liver via the bloodstream. The liver will then convert the lactic acid to pyruvate via the enzyme lactate dehydrogenase, which consumes cytosolic NAD+ in the reaction. Pyruvate is then metabolized to glucose via the gluconeogenic pathway, and glucose is sent into the bloodstream for use by the other organs. Ethanol is processed by the liver via alcohol dehydrogenase. Alcohol dehydrogenase consumes cytosolic NAD+ to metabolize the ethanol. As a consequence, the pool of NAD+ available for lactate dehydrogenase is significantly reduced, thereby supressing the conversion of lactate to pyruvate and subsequent gluconeogenesis, thereby creating a state of hypoglycemia, presenting with the symptoms described. O C. Anaerobic exercise leads to an accumulation of lactic acid in the muscle, which is sent to the liver via the bloodstream. The liver will then convert the lactic acid to ethanol via the combined action of the enzymes lactate dehydrogenase and alcohol dehydrogenase, which increases the amount of ethanol in the bloodstream even further. O D. Anaerobic exercise leads to an accumulation of puruvate in the muscle, which is sent to the liver via the bloodstream. The liver will then convert the excess pyruvate to lactic acid via the enzyme lactate dehydrogenase, which consumes cytosolic NAD+ in the reaction. Lactic acid is then metabolized to glucose via the gluconeogenic pathway, and glucose is sent into the bloodstream for use by the other organs. Ethanol is processed by the liver via alcohol dehydrogenase. Alcohol dehydrogenase consumes cytosolic NADH to metabolize the ethanol. As a consequence, the pool of NAD+ available for lactate dehydrogenase is significantly reduced, thereby supressing the conversion of puruvate to lactate and subsequent gluconeogenesis, thereby creating a state of hypoglycemia, presenting with the symptoms described. Question Com Several players on the GMU Ice Hockey team elect to hit the pub immediately after an intense and strenuous practice session involving a lot of anaerobic excercise. Without ordering food, they each consume 8 shots of whiskey in a -90 minute period. Shortly thereafter the players begin to experience shakiness, sweating, headache, nausea, uneven heartbeat, fatigue, irritability, problems concentrating, dizziness, lightheadedness, tingling or numbness of the lips and tongue, confusion, loss of coordination, and slurred speech with blurry vision. The next day they brush it off as symptoms of being drunk. On the other hand, their hockey coach knows that to metabolize the ethanol present in the whisky they consumed, their liver utilizes the enzyme alcohol dehydrogenase (ADH). In addition to intoxication, coach also suspects the player's symptoms reflect a state of hypoglycemia (low blood glucose level) as a result of their imbibing. NAD+ NADH + H+ CH3CH2OH ethanol ADH CH3CHO acetaldehyde NADH A+ H+ CO2 Lactate NAD+ HOH ✗CO2 GMU Ice Hockey 2023-2024 MASON