Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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Carboxylic acid reacts with an amine to form an amide. The reaction proceeds by the nucleophilic addition reaction mechanism.
Amide is the most stable carboxylic acid derivative and it is formed easily by the reaction of carboxylic acid and amine. Carboxylic acid reacts with a primary amine N-alkyl amide will be formed. If a carboxylic acid reacts with a secondary amine N, N-dialkyl amide will be formed.
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