Question 31 PART I-Problem Solving A clinical geneticist is investigating a new, rare syndrome, which is believed to be a single gene disorder. The symptoms include impaired cellular respiration, decreased exercise tolerance, and progressive nerve cell death. Filled squares are affected individuals, and the intensity of the shading indicates the severity of the symptoms. Open squares are individuals that show no symptoms. Those marrying in from outside the family can be assumed o be normal genotype. A. What is the mode of inheritance of this condition? Give your reasoning. (21) B. Individual i is asymptomatic but has passed on the disease. Give TWO terms that are appropriate to describe this situation in context. (6) C. What is the risk to future children of individual ii and why? (6)

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Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.