Question 3 [10] 3.1. (i) Describe the differences between a linear ToF mass spectrometer and an orthogonal ToF instrument. (2) (ii) What are the advantages and limitations of these two geometries? (3) (3) 3.2. Describe three ways of introducing a sample into an ICP torch. 3.3. A chromatogram of a mixture of compound X and Y provided the following data (see Table 3.1): Table 3.1: Chromatographic data for U and V 3 Retention time (min) Mobile phase peak 0.81 Compound X 9.35 Compound Y 10.76 Peak width (at base) 0.01 1.13 1.19 (i) For compound X, calculate (correct to 3 sig figs) its retention factor. (1) (ii) Calculate (correct to 3 sig figs) the selectivity factor for compound X and Y. (1)

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1,3,5 what the correct answer?

Kk.312.

QUESTION T5 Why were the areas underneath the peaks in the gan chromatographs you eobtained mutiplied by a weight tactor? DA the corrction factor compensates for user error OB Rame lonization detectors (FID) respond slightly dfferent to compounds with diferent molecular weights OCnone of the answers OD. the GC (GOW MAC 350) used contains a quadrapole mass spec detector whose response must be corrected for the miz ratio of the diferent ions obtainen for diferert moleculestune OE not all molecules have the same themmal conductivity QUESTION 16 Which list of functional groups is present in the anti-viral drug Arbidol HO Br O A Thioether, alkene, ester, amide, amine O 8. Thioether alcohol, ester, amine OC Alcohol, ether, amide, epoxide, thioester OD. Ether, ketone olefin, amine, alcohol O E Thioalcohol, alkene, ether, amine, nitro

Directions: (1) Determine the total volume of the standards by using a formula in the appropriate boxes (your instructor will help you with this). (2) Determine the concentration of Cu2+ in each standard, also using a formula in the appropriate cells. (3) Plot the absorbance as a function of Cu2+ concentration. Determine the equation for the best-fit line. 1.0 M ethylenediamine (mL) concentration Cu2+ absorbance (AU) at 550 nm 0.01 M CuSO4 5H2O H2O total volume stock Cu2+ standard (mL) (mL) (mL) (units) concentration (M) 1 0.50 0.00 9.50 0.025 0.01 2 0.50 0.50 9.00 0.031 0.01 3 0.50 1.00 8.50 0.048 0.01 4 0.50 2.00 7.50 0.153 0.01 5 0.50 3.00 6.50 0.223 0.01 0.50 4.00 5.50 0.307 0.01 7 0.50 5.00 4.50 0.384 0.01

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[1] In paper chromatography, why do some ions move only a short distance from the point of application while others move much more?

In molecular exclusion (size exclusion) chromatography, the molecules have the longest retention times. a) the larger molecules b) the smaller molecules

Question 2. (B) the DART source (direct analysis in real time) is a relatively new MS technique. What is it and how does it work? What is it useful for?