Question 1 Which of the following statements about nucleophilic reactions are generally true ? O SN2 reactions rely on least hindered substrates. 1° are best while 3* are worst. O SN1 and E1 reactions rely on good carbocation forming substrates. Benzylic, allylic, 3° are best while 1° are worst. O E2 reactions depend primarily on strong bases like hydroxides, alkoxides, or amides. Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are favoring SN2. O Polar protic, neutral or acidic solvents/environments like alcohols, water, or acidic solutions favor SN1/E1 mechanisms. O SN2 and E2 reactions are stereospecific, while SN1 occurs with racemization. Elimination reactions are expected to result in Zaitsev's (more substituted) product(s), unless hinderance steers them into Hoffman's (less substituted) product(s).

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question

Not sure which ones are correct

Question 1
Which of the following statements about nucleophilic reactions are generally true ?
O SN2 reactions rely on least hindered substrates. 1° are best while 3° are worst.
SN1 and E1 reactions rely on good carbocation forming substrates. Benzylic,
allylic, 3° are best while 1° are worst.
O E2 reactions depend primarily on strong bases like hydroxides, alkoxides, or
amides.
Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are
favoring SN2.
O Polar protic, neutral or acidic solvents/environments like alcohols, water, or
acidic solutions favor SN1/E1 mechanisms.
SN2 and E2 reactions are stereospecific, while SN1 occurs with racemization.
Elimination reactions are expected to result in Zaitsev's (more substituted)
product(s), unless hinderance steers them into Hoffman's (less substituted)
product(s).
Transcribed Image Text:Question 1 Which of the following statements about nucleophilic reactions are generally true ? O SN2 reactions rely on least hindered substrates. 1° are best while 3° are worst. SN1 and E1 reactions rely on good carbocation forming substrates. Benzylic, allylic, 3° are best while 1° are worst. O E2 reactions depend primarily on strong bases like hydroxides, alkoxides, or amides. Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are favoring SN2. O Polar protic, neutral or acidic solvents/environments like alcohols, water, or acidic solutions favor SN1/E1 mechanisms. SN2 and E2 reactions are stereospecific, while SN1 occurs with racemization. Elimination reactions are expected to result in Zaitsev's (more substituted) product(s), unless hinderance steers them into Hoffman's (less substituted) product(s).
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Tools in Analytical Chemistry
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY