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Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.

Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.
Transcribed Image Text:Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.
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In zero order reaction rate is independent of initial concentration of reactants.

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