Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.

Chemistry: Principles and Reactions
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Author:William L. Masterton, Cecile N. Hurley
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Chapter11: Rate Of Reaction
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Problem 37QAP: The first-order rate constant for the decomposition of a certain hormone in water at 25C is...
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Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug
per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug
in solution undergoes first-order decomposition and decomposes to 75% of the initial
concentration in 400 hours.
a) Determine the zero-order rate constant.
b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.
Transcribed Image Text:Q. 2 An aqueous suspension dosage form is prepared which contains 150 mg of drug per ml of suspension. The equilibrium solubility of the drug in water is 11 g/L. The drug in solution undergoes first-order decomposition and decomposes to 75% of the initial concentration in 400 hours. a) Determine the zero-order rate constant. b) Assuming that the shelf-life of a drug is t10%, calculate the shelf-life.
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In zero order reaction rate is independent of initial concentration of reactants.

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