Put the steps of excitation-contraction in order: 1 Myosin "heads" pivot, cause [ Choose ] Calcium is taken back up and the muscle relaxes Action potential triggers Ca2+ release from sarcoplasmic reticulum ACh produces large EPSP in muscle fiber Muscle contracts Binding of Ca2+ to troponin causes myosin to bind to actin 5. EPSP evokes muscle action potential 6. Alpha motor neurons release ACh Myosin "heads" pivot, cause filaments to walk along filament [Choose] 8. [Choose ] 2. 3. 4.

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### Steps of Excitation-Contraction Coupling

#### Instructions: 
Put the following steps of excitation-contraction in order. 

1. **Myosin "heads" pivot, cause filaments to walk along filament**
2. **[Choose]**
3. **[Choose]**
4. **[Choose]**
5. **[Choose]**
6. **[Choose]**
7. **[Choose]**
8. **[Choose]**

#### Available Options to Choose From:
- Calcium is taken back up and the muscle relaxes
- Action potential triggers Ca2+ release from sarcoplasmic reticulum
- ACh produces large EPSP in muscle fiber
- Muscle contracts
- Binding of Ca2+ to troponin causes myosin to bind to actin
- EPSP evokes muscle action potential
- Alpha motor neurons release ACh
- Myosin "heads" pivot, cause filaments to walk along filament 

Select the appropriate sequence for each step based on the process of excitation-contraction in muscle fibers. The provided options cover critical steps such as action potential generation, Ca2+ release, binding of Ca2+ to troponin, and the role of ACh.

#### Explanation of Terms:

1. **Alpha Motor Neurons Release ACh (Acetylcholine):** This step involves the release of ACh from the neuron which will bind to receptors on the muscle fiber.
2. **ACh Produces Large EPSP in Muscle Fiber:** The binding of ACh results in an excitatory postsynaptic potential (EPSP) in the muscle fiber, leading to depolarization.
3. **EPSP Evokes Muscle Action Potential:** The large EPSP triggers an action potential in the muscle fiber, propagating along its membrane.
4. **Action Potential Triggers Ca2+ Release from Sarcoplasmic Reticulum:** The action potential leads to the release of calcium ions (Ca2+) from the sarcoplasmic reticulum into the cytoplasm of the muscle cell.
5. **Binding of Ca2+ to Troponin Causes Myosin to Bind to Actin:** Calcium ions bind to troponin, inducing a conformational change that allows myosin to attach to actin filaments.
6. **Myosin "Heads" Pivot, Cause Filaments to Walk Along Filament:** The pivoting of myosin heads generates force, causing the actin and myosin filaments to slide past
Transcribed Image Text:### Steps of Excitation-Contraction Coupling #### Instructions: Put the following steps of excitation-contraction in order. 1. **Myosin "heads" pivot, cause filaments to walk along filament** 2. **[Choose]** 3. **[Choose]** 4. **[Choose]** 5. **[Choose]** 6. **[Choose]** 7. **[Choose]** 8. **[Choose]** #### Available Options to Choose From: - Calcium is taken back up and the muscle relaxes - Action potential triggers Ca2+ release from sarcoplasmic reticulum - ACh produces large EPSP in muscle fiber - Muscle contracts - Binding of Ca2+ to troponin causes myosin to bind to actin - EPSP evokes muscle action potential - Alpha motor neurons release ACh - Myosin "heads" pivot, cause filaments to walk along filament Select the appropriate sequence for each step based on the process of excitation-contraction in muscle fibers. The provided options cover critical steps such as action potential generation, Ca2+ release, binding of Ca2+ to troponin, and the role of ACh. #### Explanation of Terms: 1. **Alpha Motor Neurons Release ACh (Acetylcholine):** This step involves the release of ACh from the neuron which will bind to receptors on the muscle fiber. 2. **ACh Produces Large EPSP in Muscle Fiber:** The binding of ACh results in an excitatory postsynaptic potential (EPSP) in the muscle fiber, leading to depolarization. 3. **EPSP Evokes Muscle Action Potential:** The large EPSP triggers an action potential in the muscle fiber, propagating along its membrane. 4. **Action Potential Triggers Ca2+ Release from Sarcoplasmic Reticulum:** The action potential leads to the release of calcium ions (Ca2+) from the sarcoplasmic reticulum into the cytoplasm of the muscle cell. 5. **Binding of Ca2+ to Troponin Causes Myosin to Bind to Actin:** Calcium ions bind to troponin, inducing a conformational change that allows myosin to attach to actin filaments. 6. **Myosin "Heads" Pivot, Cause Filaments to Walk Along Filament:** The pivoting of myosin heads generates force, causing the actin and myosin filaments to slide past
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