Propose an efficient synthesis for the following transformation: The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer. A В C H20, H2SO4, H8SO4 Br2 CH3CH21, NANH2 E F HBr H2, Lindlar's catalyst Na, NH3 () H. 1) xs NaNH2 2) H20 HBr, ROOR H2, Pd
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
![**Efficient Synthesis Problem**
**Transformation Goal:**
Propose an efficient synthesis for the following transformation:
![Transformation Diagram]
The diagram illustrates the transformation of a starting alkyne into a target alkyne with an additional functional group.
**Instructions:**
The transformation can be performed using some reagents or combinations listed below. Provide the necessary reagent(s) in the correct order as a string of letters (without spaces or punctuation, such as "EBF"). If there is more than one correct solution, provide just one answer.
**Reagents List:**
| Letter | Reagent(s) |
|--------|--------------------------------------------|
| A | H₂O, H₂SO₄, HgSO₄ |
| B | Br₂ |
| C | CH₃CH₂I, NaNH₂ |
| D | HBr |
| E | H₂, Lindlar's catalyst |
| F | Na, NH₃ (l) |
| G | 1) excess NaNH₂, 2) H₂O |
| H | HBr, ROOR |
| I | H₂, Pd |
**Task:**
- Identify the correct sequence of reagents to achieve the desired transformation.
- List the sequence as a string of letters, for example, "EBF."
**Note:**
Before attempting the synthesis question, ensure you understand the specific role of each reagent in alkyne reactions. This will help you determine the most efficient pathway to achieve the desired product.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1131871b-8c87-406d-9807-6125c8d6ca38%2F97632346-5a19-4b95-a494-1453aa426848%2Flpi26zj_processed.jpeg&w=3840&q=75)
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