Propose an efficient synthesis for the following compounds using the malonic ester or the acetoacetic ester synthesis, giving all the steps required in the synthesis. Reagents and conditions for each step must be given. Mechanisms are not required. " or a) 2 OH "Orio" ore b) OH

Q: Cl -OCH₂CO₂H Show how 2,4-Dichlorohenoxyacetic acid or 2, 4-D can be 2,4-dichlorophenoxyacetic acid…

A: Phenols react with NaOH and gives phenoxide ion. Phenoxide react with alkyl halide gives phenoxy…

Q: 21 of 42 Current Attempt in Progress A Propose an efficient synthesis for the given transformation.…

A: DCM Explanation:Step 1: Reaction Mechanism Step 2: Alkyl halide reacts with Mg to form the Grignard…

Q: An a,ß-unsaturated carbonyl compound can be prepared by a reaction known as a…

A: LDA is used to abstract the ‘H’ from the less hindered side to form the carbanion. Since both the…

Q: Choose the set of letters corresponding to the best answer. WRITE IN CAPITAL LETTERS. ABC DEF GHI…

A: 1) JKL 2) GHI ,because after oxidation of ketone give alcohol and at alpha position CH3 group is…

Q: 3. The following reaction is used in the industrial synthesis of the antiviral drug, oseltamivir…

A: This problem is based on deprotactation and protection of diols by using different type of…

Q: An acetal produces the following three compounds upon hydrolysis. Of acetals A-E which could it be?…

A: The given products and the options for the reactants are shown below.We have to determine the…

Q: Draw the major product of this reaction. Ignore inorganic byproducts and the carboxylic acid side…

A: LiAl(OR)3H is the bulkier  reducing agent . Reaction is in -78°C , anhydride will convert to…

Q: Devise a synthesis of compund 1 starting from ethyl acetoacetate. You should include details of all…

A:

Q: HO LOR H3O+ OH LOR

A: This is an example of enolate formation of carbonyl compound in acidic medium

Q: 20. Propose an efficient synthesis for the following transformation: OH ÓH

A:

Q: #Q "

A: The question is based on the concept of organic synthesis.  we need to synthesize the product using…

Q: tayo HO NH₂ starting material

A:

Q: Which method would you use to perform these reactions, Grignard carboxylation, nitrile hydrolysis,…

A: Grignard carboxylationExplanation:In all the reactions, Grignard carboxylation is performed.  Here,…

Q: + en

A:

Q: 2) Identify the base that is best suited to do the following conversion.

A: Given : structure of reactant and products. First is Hoffman elimination Second is E2 elimination

Q: The pharmaceutical drug, Celecoxib, canbe made through a condensation of a substituted aryl…

A: The objective of the question is to provide a mechanism for the transformation of a substituted aryl…

Q: Ph OH OH OH Ph OH OH

A: The question is based on the concept of organic synthesis.We need to synthesize the product using…

Q: Salsolinol is a naturally occurring compound found in bananas,chocolate, and several foods derived…

A: In this question, we will draw a step by step mechanism.  You can see details mechanism below.

Q: 2 ОН Н H H₂O+/H₂O НО ОН

A: An arrow always depicts from a region of high electron density to low electron density ; that is…

Q: 3. Complete the following synthesis using any reagents of your choice: Me Me COOH

A:

Q: Identify the best reagents to complete the following reaction. o OH B C D E DMP (Dess-Martin…

A:

Q: 4. Determine the appropriate reagents to achieve the following transformations. 요 Η Ph Ph Η

A: Step 1:To achieve the transformations shown in the image, we need to determine the appropriate…

Q: Propose a synthesis for lactone B starting from hydroxy-aldehyde A. Show the required reagents and…

A: The objective of this question is to draw a multi-step synthesis pathway to achieve a target…

Q: a) Ketoacid Z below can be synthesized from ethyl acetoacetate W via an acetoacetic ester synthesis.…

A:

Q: 1. Suggest the synthesis (state the necessary reagents) for the following ketones using acetoacetic…

A: The objective of the question is to suggest a synthesis pathway for the given ketones using…

Q: 5. Predict the product of the reaction sequence OEt NaOEV/HOEt Br(CH₂),Br 1. Br₂/ACOH 2. pyridine…

A:

Q: Propose a synthesis of the anti-inflammatory drug Ibuprofen from benzene. Show all reagents and all…

A: The complete synthesis of Ibuprofen from benzene is given below-

Q: 1) 12, NaOH, H20 2 OH + ICH3 2 2) Hо* Draw a detailed mechanism with arrows showing the movement of…

A: Here we are required to show the mechanism for formation of benzoic acid from1,3 diphenyl…

Q: Question 5 Using the reagent sheet, identify the reagent needed to carry out the transformation…

A: Given reaction,

Q: Using the reagent sheet, identify the reagent needed to carry out the transformation below. Enter…

A: The reaction taking place is given as,

Q: 1. Provide missing reagents or products in the following synthesis: он Br 1) ОН, 100°С NH3 2) H,О 2.…

A:

Q: Propose a synthesis for the following compound from benzene. Draw the formation of each Super E* for…

A: Given target molecule is prepared from benzene  by electrophilic aromatic substitution reaction.

Q: Sive necessary reagents to complete the synthesis elow OH

A: The question is based on the concept of organic synthesis.We need to synthesize the product using…

Q: Provide the intermediates, reagents, and product needed to complete this synthesis. Ignore inorganic…

A: The given reactions involves multiple steps.  At first reduction of nitrobenzene occurs by Fe in HCl…

Q: Propose a synthesis for each ketone, using as one step in the sequence a Claisen condensation and…

A: The given chemical reaction is, The sodium ethoxide would abstract an alpha hydrogen from the…

Q: Propose a synthesis for each ketone, using as one step in the sequence a Claisen condensation and…

A:

Q: OH CH₂CNHCH3 CH3 C d OH CHCHNHCH₂ CH3 Ephedrine can be synthesized via reductive amination plus…

A:

Q: Draw the products of the following reactions.

A: Given are organic reactions. Given compounds have nitrile group.The given reactions occur through…

Q: How can the following compounds be prepared from a carbonyl compound that has one less carbon than…

A: a) The starting material for the synthesis of this two carbon compound must be formaldehyde.…

Q: 3. Provide a mechanism for the following transformation: Ph CI (2 eq.) 2 eq. NaCN 4. Provide a…

A:

Q: 2. Propose a synthesis of the following molecule using an aldol reaction. OH

A: Aldol condensation:Two carbonyl compounds joined together by the formation of carbon-carbon bond…

Q: What is the product formed by hydrolysis of the following lactone with acid? А. ос B. H3O+ ОН с. OH…

A:

Q: b) from HOCH₂CH₂CH₂CH₂OH 3. Propose a mechanism for the following reaction: OH T™ H+ cholen ssos H₂O

A:

Q: CH3 C₂H5O₂C NH₂

A: The question is based on the concept of organic synthesis.We need to synthesize the product using…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.