Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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I have proposed a suitable synthesis for the following transformation please let me know whether or not this is correct. If incorrect please let me know what I did wrong.
Transcribed Image Text:**Title: Propose a Suitable Synthesis**
**Header:** Synthesis Steps
**Text and Diagram Explanation:**
1. **Reactants and Reagents:**
- The synthesis begins with a benzene ring attached to a carbon chain with a protected alcohol group.
- The first reaction shows the use of lithium aluminum hydride (LiAlH₄) followed by hydronium ion (H₃O⁺), which suggests a reduction step.
2. **Formation of Brominated Product:**
- The second step involves PBr₃, which is typically used to convert alcohols to alkyl bromides, indicating the conversion of a hydroxyl group to a bromine atom on a benzene ring.
3. **Grignard Reagent Formation:**
- The next step involves magnesium in dry ether, converting the alkyl bromide to a Grignard reagent (R-MgBr).
4. **Grignard Reaction with Carbonyl:**
- In a separate reaction, a ketone group is treated with the Grignard reagent, forming a tertiary alcohol. The conditions indicated are:
1) Reaction of the carbonyl compound with Grignard reagent.
2) Protonation with H₃O⁺ to yield the final product.
5. **Oxidation:**
- The tertiary alcohol product goes through oxidation with PCC (pyridinium chlorochromate) to form a ketone structure.
**Summary:**
This process illustrates the transformation of a benzene-derived alcohol through a series of reductions, brominations, Grignard reactions, and oxidations to synthesize a benzophenone derivative. The mechanisms and reagents are indicative of fundamental organic synthesis techniques used to manipulate functional groups and carbon backbones effectively.
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