Pro- inflammatory chemicals Blood clot Bacteria entering via wound Inflammatory mediators are released response to microbial components and tissue damage. Phagocytic cells destroy and remove invaders. -Neutrophil Resident macrophage Blood vessel Neutrophil -Recruited macrophage 20 Monocyte Leaky capillary Neutrophils are the first phagocytes recruited to the site. Normal blood flow in the tissues As the infection is brought under as the injury occurs. control, macrophages ingest dead cells and debris. (a) Tighter Diapedesis Loose adherence; adherence cells tumble to a halt. Inflammatory mediators cause small blood vessels to dilate. The phagocytic cells tumble to a halt and then squeeze between the endothelial cells and enter the tissues. (Ь) FIGURE 14.15 The Inflammatory Response (a) The process of inflammation. (b) Phagocytes leave the blood vessels and move to the site of infection.

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