Present a synthetic route reported in the literature for the synthesis of the captopril from commercially available materials. Indicate the yield of each step and in the case of multi-step reactions the overall yield.

Present a synthetic route reported in the literature for the synthesis of the captopril from commercially available materials. Indicate the yield of each step and in the case of multi-step reactions the overall yield.

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter11: Ethers, Epoxides, And Sulfides

Section: Chapter Questions

Problem 11.37P: Following are the steps in the industrial synthesis of glycerin. Provide structures for all...

See similar textbooks

Similar questions

Following are the steps in the industrial synthesis of glycerin. Provide structures for all intermediate compounds (AD) and describe the type of mechanism by which each is formed.
Assuming that benzaldehyde is the limiting reagent for the synthesis of stilbene, that stilbene is the limiting reagent for the synthesis of stilbene dibromide, and that stilbene dibromide is the limiting reagent for the synthesis of diphenylacetylene; what is the overall % yield of diphenylacetylene from benzaldehyde given the percentage yield of each step of the reaction sequence as follows? Give only two significant digits. If the answer is a whole number with two digits, do not include the decimal. 52% 87% benzaldehyde → stilbene → stilbene dibromide 41% Answer: diphenylacetylene Notes: For our multi-step synthesis we cannot just calculate the yield based on starting amount of benzaldehyde and final amount of diphenylacetylene because your group may have been supplemented with commercial material at one or more steps. In truth most chemist use an excess of the least expensive reagent to increase their yield. So in our case benzyltriphenylphosphonium chloride should probably be our…
Assuming that benzaldehyde is the limiting reagent for the synthesis of stilbene, that stilbene is the limiting reagent for the synthesis of stilbene dibromide, and that stilbene dibromide is the limiting reagent for the synthesis of diphenylacetylene; what is the overall % yield of diphenylacetylene from benzaldehyde given the percentage yield of each step of the reaction sequence as follows? Give only two significant digits. If the answer is a whole number with two digits, do not include the decimal. benza Idehy de Notes: 66% stil be ne 23% stilbene dibromi de 66% dipheny lacetyle ne
the organic compound 2-heptanone, belonging to the ketone family, is responsible for the strong penetrating odor in Roquefort cheeses. Starting from acetylene as the starting reagent, propose a synthesis line with the reaction mechanisms involved for the synthetic obtaining of 2-heptanone and use it as a food additive in analogous cheeses.
Write the reaction flow chart fir the following condensation and further heating of resulting products
( plz with detail explanation )
Restate the paragraph. The main objective of the laboratory activity was to make aspirin also known as acetylsalicylic acid in its scientific name. It was successfully done as aspirin was synthesized using the combination of salicylic acid and acetic anhydride. In this reaction, salicylic acid's hydroxyl group on the benzene ring interacted with acetic anhydride to generate an ester functional group. This is an esterification reaction that produces acetylsalicylic acid. Sulfuric acid was utilized as a catalyst to start the esterification reaction. Some unreacted acetic anhydride and salicylic acid, as well as sulfuric acid, aspirin, and acetic acid, remained in the solution after the reaction was completed. The process of crystallization was used to obtain pure crystals of a substance from an impure mixture. Upon completion of the lab, analysis, and calculations, , it is evident that the synthesis of aspirin is possible using these methods but that the yield will be relatively low
The reaction between propanoic acid and benzyl alcohol in an acidic medium. Show the product by writing the reaction together with its mechanism.
Assuming that cyclohexanone is the limiting reagent for the synthesis of cyclohexanone oxime and that cyclohexanone oxime is the limiting reagent for the synthesis of caprolactam; what is the overall % yield of caprolactam from cyclohexanone given the percentage yield of each step of the reaction sequence as follows? Give only two significant digits. If the answer is a whole number with two digits, do not include the decimal. 57% 27% cyclohexanone → cyclohexanone oxime → caprolactam Answer:
Using chemical structures draw the complete chemical reaction of Acetone with benzaldehyde under basic conditions, provide both the major and minor products.
A problem often encountered in the oxidation of primary alcohols to acids is that esters are sometimes produced as by-products. For example, oxidation of ethanol yields acetic acid and ethyl acetate: Propose a mechanism to account for the formation of ethyl acetate. Take into account the reversible reaction between aldehydes and alcohols:
Show how to bring about each step in this synthesis of the herbicide propranil.